The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. The expanding array of new targeting molecules (recombinant antibodies or peptides) may increase the therapeutic efficacy. The title of this book "Targeted Radionuclide Tumor Therapy – Biological aspects" was selected to reinforce the concept that a major focus was devoted to understanding the biological effects of targeting and radiation. Furthermore, our rapidly expanding knowledge of low dose-rate effects, different types of cell death, autosensitization and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
The development of targeted therapy is a true multidisciplinary enterprise involving physician scientists from the fields of nuclear medicine, radiation therapy, diagnostic radiology, surgery, gynaecology, pathology and medical oncology/haematology. It also involves many preclinical scientists working with experimental animal models, immunochemistry, recombinant antibody technologies, radiochemistry, radiation physics and basic cell biology.
It is the ambition of the editors to enable deeper insights in the process of improving targeted therapy. We believe that the time now has come when targeted therapy can soon be added to standard oncology treatment regimens.
Content Level » Research
Keywords » Cancer Treatment - Cure vs Palliation - Monoclonal Antibodies - Radioimmunotherapy - Targeted Tumor Therapy
Related subjects » Cancer Research - Nuclear Medicine - Oncology & Hematology - Radiology
TABLE OF CONTENTS
List of contributor
1. INTRODUCTION TO RADIONUCLIDE THERAPY; J. Carlsson et al. 2. THERAPEUTICALLY USED ANTIGENS IN RADIOIMMUNOTHERAPY; T. Stigbrand et al. 3. EGFR-FAMILY EXPRESSION AND IMPLICATIONS FOR TARGETED RADIONUCLIDE THERAPY; J. Carlsson 4. TARGETING TUMORS WITH RADIOLABELED ANTIBODIES; T. Stigbrand et al. 5. ANTOBODY FRAGMENTS PRODUCED BY RECOMBINANT AND PROTEOLYTOC METHODS; G. Adams 6. NOVEL ALTERNATIVE SCAFFOLDS AND THEIR POTENTIAL USE FOR TUMOR TARGETED RADIONUCLIDE THERAPY; F. Nilsson 7. PEPTIDES FOR RADIONUCLIDE THERAPY; M. de Jong et al. 8. CHOICE OF RADIONUCLIDES AND RADIOLABELLING TECHNIQUES; V. Tolmachev 9. HIGH-LET-EMITTING RADIONUCLIDES FOR CANCER THERAPY; G. Sgouros 10. TARGETED HIGH-LET THERAPY OF BONE METASTASES; Ø. S. Bruland et al. 11. THE AUGER EFFECT IN MOLECULAR TARGETING THERAPY; H. Lundqvist et al. 12. RADIATION INDUCED CELL DEATHS; D. Eriksson et al. 13. RADIATION INDUCED DNA-DAMAGE/REPAIR AND ASSOCIATED SIGNALING PATHWAYS; B. Stenerlöw et al. 14. RADIATION INDUCED DNA DAMAGE CHECKPOINTS; D. Eriksson et al. 15. CANCER STEM CELLS AND RADIATION; D. Eriksson et al. 16. EFFECTS OF LOW DOSE-RATE RADIATION ON CELLULAR SURVIVAL; J. Carlsson 17. BYSTANDER EFFECTS AND RADIONUCLIDE THERAPY; K. M. Prise 18. ENHANCING THE EFFICIENCY OF TARGETED RADIONUCLIDE TREATMENT; G. Adams 19. LOW DOSE HYPERRADIOSENSITIVITY: A HISTORICAL PERSPECTIVE; B. Marples et al. 20. CLINICAL RADIONUCLIDE THERAPY: A. Scott and S. Lee 21. DEVELOPMENT TRENDS IN TARGETED THERAPY-BIOLOGICAL ASPECTS; T. Stigbrand et al.
From the reviews:
"This book is devoted to understanding the biological aspects of targeted radiotherapy and discusses in depth the various targeting agents as well as the radiopharmaceuticals used in targeted therapy. … Physicians, physicians in training, and physicists who use radionuclide targeted agents in the specialties of radiation oncology, medical oncology, and nuclear medicine are the intended audience. … Overall this is a very informative book for physicians particularly interested in the biological aspects of targeted radiotherapy." (James G. Douglas, Doody’s Review Service, November, 2009)