Mitochondrial Medicine. Mitochondrial Metabolism, Diseases, Diagnosis and Therapy

About this book

Mitochondrial medicine, a relatively new area, deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. A primary feature of mitochondrial dysfunction is impaired cellular bioenergetics.

This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience and state-of-the-art knowledge in various fields of their expertise such as mitochondrial cardiology, neurology, diabetology, nephrology, immunology, rheumatology, reproductive medicine, sports medicine, and chronobiology. They also guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Mitochondrial Medicine is dedicated to Dr. Frederick L. Crane, discoverer of Coenzyme Q<SUB>10</SUB> in 1957 and to the celebration of the 50th year of its discovery. It is ideal for general medical practitioners, for specialists such as cardiologists, neurologists, and diabetologists, biochemists, nutritionists, pharmacists, and also for graduate students.

Written for: Physicians, practitioners and clinicians, post-graduates in neurology, cardiology, diabetology, nephrology, immunology, rheumatology, andrology, sports medicine

Table of contents

List of Contributors.- Dedication.- Preface.- Acknowledgements.- List of Figures.- Mitochondrial physiology.- Oxidants, antioxidants and oxidative stress.- Chronobiology, chronomics and N-of-1 tests of timing coenzyme Q10.- Methods of chronobiometric analysis of mitochondrial function.- Mitochondrial medicine.- Mitochondrial cardiology.- Mitochondria of the human transplanted heart.- Mitochondrial diabetology.- Mitochondrial nephrology.- Mitochondria of skeletal muscle.- Rheumatoid arthritis.- Mitochondrial immunology.- Mitochondrial “spermatopathy”.- Methods for diagnosis of mitochondrial diseases.- Nuclear Magnetic Resonance.- Clinical aspects of coenzyme Q10 in relationship with its bioenergetic and antioxidant properties.- Coenzyme Q10 supplementation in clinical medicine.- Coenzyme Q10 supplementation in experimental medicine.- w -3-PUFA, w -6-PUFA.- Carnitine.- Vitamins in mitochondrial function.- Polarized light.