Oxidation: The Cornerstone of Carcinogenesis

About this book

In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject.

This book is unique due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner.

This book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.

Written for:

Researchers in oncology and oncologists, researchers in molecular biology, medical doctors, graduate and post-graduate medical and biology students, libraries, pharmaceutical industry and related research institutes

Keywords:

Genetic mutations, Cancer, Carcinogenesis, oxidative stress, Free radicals, tobacco smoke

Table of contents

Chapter 1: Oxygen and Nitrogen free radicals
Chapter 2: Oxidative stress
Chapter 3: Oxidative damage of genome DNA: repair mechanisms
Chapter 4: Mitochondria: structure, function and relationship with carcinogenesis
Chapter 5: Oxidative activation of transcription factor pathways by cigarette smoke oxidants
Chapter 6: Cell protection mechanisms from oxidation
Chapter 7: Role of DNA adducts in carcinogenesis
Chapter 8: Transmolecular reactions of genetic toxicity: alkylation and methylation of DNA
Chapter 9: Toxicity and carcinogenicity of hydrocarbons
Chapter 10: Toxicity and carcinogenicity of the aromatic hydrocarbons
Chapter 11: Toxicity and carcinogenicity of aldehydes
Chapter 12: Toxicity and carcinogenicity of the nitriles
Chapter 13: Toxicity and carcinogenicity of the eterocyclic organic compounds
Chapter 14: Toxicity and carcinogenicity of metals
Chapter 15:Oxidative profile of cigarette smoke and lung cancer
Chapter 16: Smoking and lung cancer