Metabolic Syndrome and Neurological Disorders

Description

Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders.

Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.

Table of Contents

Foreword Mark P. Mattson
Preface Tahira Farooqui and Akhlaq A. Farooqui
Acknowledgments Tahira Farooqui and Akhlaq A. Farooqui
Contributors

1 Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease
Suzanne M. de la Monte and Ming Tong

2 Insulin Receptor and the Pathophysiology of Alzheimer Disease
Johanna Zemva and Markus Schubert

3 Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease
Adnan Erol

4 Insulin–Leptin Signaling in the Brain
Vicente Barrios, Emma Burgos-Ramos, and Jesús Argente

5 The Janus Face of Insulin in Brain
Ana Duarte, Emanuel Candeias, Sónia C. Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I. Plácido, Maria S. Santos, Catarina R. Oliveira, and Paula I. Moreira

6 Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease
Maite Solas and Maria J. Ramírez

7 Contribution of Phospholipid, Sphingolipids, and Cholesterol-Derived Lipid Mediators in the Pathogenesis of Metabolic Syndrome and Neurological Disorders
Akhlaq A. Farooqui and Tahira Farooqui

8 Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated Neurotoxicity
Mundelanji C. Vestergaard, Masamune Morita, Tsutomu Hamada, and Masahiro Takagi

9 Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals
Giulio Maria Pasinetti, Amanda Bilski, Lap Ho, Jun Wang, Mario Ferruzzi, Masahito Yamada, Kenjiro Ono, and Salvatore Mannino

10 Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction
Jae-Sung Lim and Hyung-Min Kwon

11 Neurochemical Linkage Among Metabolic Syndrome, Alzheimer Disease, and Depression
Undurti N. Das

12 Alterations in the Endocannabinoid System as a Link Between Unbalanced Energy Homeostasis, Neuroinflammation, and Neurological and Neuropsychiatric Disorders
Tiziana Bisogno and Vincenzo Di Marzo

13 Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides
George Anderson and Michael Maes

14 Binge Eating and Metabolic Syndrome
Ignacio Jáuregui-Lobera

15 Phytochemical Principles in the Traditional Indian System of Medicine Used for the Management of Metabolic Syndrome
Syed Ibrahim Rizvi and Neetu Mishra

16 Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome
Morihiro Matsuda and Iichiro Shimomura

17 The Relationship Among Obesity, Inflammation, and Insulin Resistance
Jean-Philippe Bastard and Bruno Fève

18 Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome
Hardik Gandhi and Ramachandran Balaraman

19 Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue
Paolo Calabro, Enrica Golia, Valeria Maddaloni, Giuseppe Limongelli, Brunella Ziello, Fabio Fimiani, Ilaria Jane Romano, Mario Crisci, Maria Giovanna Russo, Edward T.H. Yeh, and Raffaele Calabro

20 Is Diabetes a Risk Factor for Parkinson Disease?
Akhlaq A. Farooqui and Tahira Farooqui

21 Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome
Lu Cai

22 Contributions of AMP Kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases
Mohamed Kodiha, Hicham Mahboubi, and Ursula Stochaj

23 Aß Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes
Naoyuki Sato and Ryuichi Morishita

24 In Vivo Evidence of the Convergence of Type 2 Diabetes and Alzheimer Disease
Sun Ah Park

25 Metabolic Syndrome and its Impact on Cardiovascular Disease
John A. Larry

26 Contribution of Inflammation, Adiponectin, and Obesity in Cardiovascular Diseases
Harald Mangge and Gunter Almer

27 Brain and Cardiovascular Diseases: Molecular Aspects
Ewa Szczepanska-Sadowska

28 Molecular Aspects of Dietary–Exercise Regimen for the Prevention of Metabolic Syndrome
Wataru Aoi

29 Ghrelin, Lipid Metabolism, and Metabolic Syndrome
Pablo B. Martínez de Morentin, Sulay Tovar, Rubén Nogueiras, Miguel López, and Carlos Diéguez

30 Leptin and Cognitive Function
Jenni Harvey

31 Fructose, Sugar Consumption, and Metabolic Diseases
Virgile Lecoultre and Luc Tappy

32 Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome
Nathalie Castanon and Sophie Layé

33 Summary and Perspective
Tahira Farooqui and Akhlaq A. Farooqui

Index

Author Information

AKHLAQ FAROOQUI is an Adjunct Associate Professor of Medical Biochemistry at Ohio State University. He is author of over 180 peer-reviewed research articles, and author/editor of eight books and an expert in fields of glycerophospholipid metabolism, excitotoxicity, bioactive ether lipids, and phospholipases A2 in brain.

TAHIRA FAROOQUI is a Research Scientist in the Department of Entomology at Ohio State University. She is the author of 40 peer-reviewed research articles and several monographs and an expert on glycerophospholipid and sphingolipid metabolism, biogenic amines, and neural plasticity.