Stem Cells in Reproductive Medicine. Basic Science and Therapeutic Potential

Description

Stem cell science has the potential to impact human reproductive medicine significantly – cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in
Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research.

The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.

Features

• Up-to-date practical information in a rapidly developing field
• New edition of a highly respected book - this is the first edition published by Cambridge University Press
• Due to the rapid developments in the field the market for this book is increasing

Table of Contents

Preface
Foreword: views from a pioneer Alan Trounson

Part I. Female Gamete:
1. Genetics of the germline formation Orkan Ilbay and Emre Seli
2. Germ cell differentiation from pluripotent cells Jose V. Medrano, Ana M. Martínez-Arroyo, Carlos Simón and Renee A. Reijo Pera

Part II. Male Gamete:
3. The male gamete Nicolás Garrido, Rocío Rivera and Marcos Meseguer
4. In vitro production of functional sperm from neonatal mouse testes Takehiko Ogawa
5. Adult stem cell population in the human testis Ellen Goossens and Herman Tournaye

Part III. The Embryo/Blastomere:
6. Meiotic recombination in human oocytes Jennifer R. Gruhn, Karl W. Broman, Patricia A. Hunt and Terry J. Hassold
7. Gene expression dynamics during human embryonic development Carlos Simón and Renee A. Reijo Pera
8. Embryonic stem cells from blastomeres maintaining embryo viability Irina Klimanskaya
9. Gamete generation from stem cells to avoid gamete donation and customized hESC from blastomeres as the cellular insurance for the newborn: will it ever be ethically acceptable? Heidi Mertes and Guido Pennings

Part IV. Trophoblast, Amniotic Fluid, Endometrium and Bone Marrow:
10. Amniotic fluid and placental membranes: unexpected sources of highly multipotent cells Sean Vincent Murphy and Anthony Atala
11. Adult stem cells in the human endometrium Caroline E. Gargett, Irene Cervelló, Hong P. T. Nguyen and Carlos Simón
12. In utero hematopoietic cell transplantation Amar Nijagal and Tippi C. MacKenzie
13. Bone marrow stroma: a source of mesenchymal stem cells for cell therapy Agustín G. Zapata

Part V. New Developments in Stem Cell Research:
14. Dedifferentiation, transdifferentiation and reprogramming Sergio Mora and Angel Raya
15. The metabolic framework of pluripotent stem cells and potential mechanisms of regulation Alexandra J. Harvey, Joy Rathjen and David K. Gardner

Index.