Prior to the use of the combined treatment of cytoreductive surgery (CRS) and perioperative chemotherapy (POC), peritoneal metastases were uniformly fatal. While the combined treatment of CRS and POC has been practiced for nearly 30 years, the benefits of the treatment are just emerging. This text is for surgical and medical oncologists, and describes the rationale, treatment, and results of treatment of peritoneal metastases, peritoneal mesothelioma, and sarcomatosis. Internationally renowned peritoneal surface oncology teams have authored the chapters. The text is accompanied by surgical video presentations which includes on-camera commentary by the international experts offering his or her own approach to CRS and POC.