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The Tgf-Beta Family
Derynck, R.
1ª Edición Enero 2008
Inglés
Tapa dura
1114 pags
2000 gr
17 x 24 x 5 cm
ISBN 9780879697525
Editorial COLD SPRING HARBOR LABORATORY
LIBRO IMPRESO
133,55 €126,87 €IVA incluido
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Description
TGF-ß is the prototype of a protein superfamily which, in humans, contains
at least 35 members, including activins, inhibins, bone morphogenetic proteins,
growth/differentiation factors, and Müllerian inhibiting substance. This
monograph draws on the world’s leading laboratories to comprehensively
cover all aspects of the biology of TGF-ß and serve as a reference work
for both specialists and researchers less familiar with the field.
Edited By Rik Derynck, University of California, San Francisco;
Kohei Miyazono, University of Tokyo
Contents
Preface
Foreword - M.B. Sporn
1. The Discovery of TGF-ß: A Historical Perspective - H.L. Moses and A.B.
Roberts
2. TGF-ß and the TGF-ß Family - R. Derynck and M. Miyazono
CELL BIOLOGY
3. TGF-ß: A Multipotential Cytokine - S.H. Schilling, A.B. Hjelmeland,
J.N. Rich, and X.-F. Wang
4. Activins and Inhibins - E. Wiater and W. Vale
5. The Bone Morphogenetic Proteins - T. Katagiri, T. Suda, and K. Miyazono
SIGNALING
6. Signaling Receptors of the TGF-ß Family - J.L. Wrana, B. Ozdamar, C.
Le Roy, and H. Benchabane
7. TGF-ß Bioavailability: Latency, Targeting, and Activation - B. Dabovic
and D.B. Rifkin
8. Agonists and Antagonists of the TGF-ß Family Ligands - C. Chang
9. TGF-ß Signaling from Receptors to Smads - C.-H. Heldin
10. Transcriptional Control via Smads - X. Lin, Y.-G. Chen, and X.-H. Feng
11. Growth Control by TGF-ß: Mechanisms Controlling Cell Cycle Progression
and Apoptosis - P.M. Siegel and J. Massagué
12. Regulation of TGF-ß Family Signaling by Inhibitory Smads - K. Miyazono
13. Structural Basis for TGF-ß Family Receptor Assembly and Signaling
Specificity - K. Lin and S. Choe
14. Non-Smad TGF-ß Signaling Pathways - Y.E. Zhang
15. Regulation of the Smad Pathway by Signaling Cross-Talk - K. Luo
DIFFERENTIATION, DEVELOPMENT, AND PHYSIOLOGY
16. TGF-ß Family Signaling in Early Postimplantation Development of the
Mouse - S. Miura, M. Whitman, and Y. Mishina
17. TGF-ß Family Signaling in Drosophila - G. Pyrowolakis, B. Hartmann,
and M. Affolter
18. TGF-ß Signaling in the Nematode C. elegans - G.I. Patterson and R.W.
Padgett
19. TGF-ß Family Signaling in Xenopus and Zebrafish Embryos - M. Whitman
20. TGF-ß Family Signaling in Stem Cell Renewal and Differentiation -
T. Watabe and K. Miyazono
21. TGF-ß Family Signaling in Mesenchymal Differentiation - R. Derynck,
E. Piek, R.A. Schneider, L. Choy, and T. Alliston
22. TGF-ß Family Signaling in Skeletal Development, Maintenance, and Disease
- T. Alliston, E. Piek, and R. Derynck
23. TGF-ß Family in Epithelial Development - N.M. Muñoz and W.M.
Grady
24. The TGF-ß Family in Endothelial Cell Differentiation and Cardiovascular
Development and Function - M.-J. Goumans, R. Carvalho, C. Mummery, and P. ten
Dijke
25. TGF-ß as a Regulator of Myeloid and Lymphoid Development and Function
- J.J. Letterio and F.W. Ruscetti
26. The TGF-ß Family in Neural and Neuronal Differentiation and Development
- J. Samanta, M.A. Bonaguidi, and J.A. Kessler
27. The TGF-ß Family in the Reproductive Tract - S.A. Pangas and M.M.
Matzuk
CANCER AND DISEASE
28. TGF-ß Signaling Pathway and Tumor Suppression - W.M. Grady and S.D.
Markowitz
29. TGF-ß Signaling in Epithelial–Mesenchymal Transition and Invasion
and Metastasis - R.J. Akhurst
30. TGF-ß and the Tumor Microenvironment - B. Bierie and H.L. Moses
31. TGF-ß and Fibrosis - E.P. Böttinger
32. Development of TGF-ß-based Therapeutic Agents: Capitalizing on TGF-ß’s
Mechanisms of Action and Signal Transduction Pathways - C.L. Arteaga and J.M.
McPherson
33. BMP-based Therapeutics and the BMP Signaling Pathways - G. Bain, A.J. Celeste,
and J.M. Wozney
Index
© 2024 Axón Librería S.L.
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