With chapters by international authorities on the subject, the text presents:
* advances in our understanding of cellular mechanisms, cell signalling, and
gene expression relevant to COPD
* new approaches that may prevent the progression of COPD
* studies on corticosteroid resistance in COPD.
Contents: Why More Research into Molecular and Cellular Mechanisms of COPD Is Needed. Inflammation in Lung Parenchyma. Small Airways Disease in COPD. Asthma versus COPD: Cellular and Molecular Differences. Airway Mucus Hypersecretion. Macrophages. Neutrophils. Epithelial Cells. T Lymphocytes. Inflammatory Mediators. Oxidative Stress. Proteinases in COPD. Antiproteases. Corticosteroid Resistance in COPD. Molecular Genetics. Mechanisms of Systemic Effects. Mechanisms of of Chronic