Part I: An Introduction to Immunobiology and Innate Immunity
Chapter 1: Basic Concepts in Immunology
Chapter 2: Innate Immunity: The First Lines of Defense
Chapter 3: The Induced Responses of Innate Immunity
Part II: The Recognition of Antigen
Chapter 4: Antigen Recognition by B-cell and T-cell Receptors
Chapter 5: The Generation of Lymphocyte Antigen Receptors
Chapter 6: Antigen Presentation to T Lymphocytes
Part III: The Development of Mature Lymphocyte Receptor Repertoires
Chapter 7: Lymphocyte Receptor Signaling
Chapter 8: The Development and of B and T Lymphocytes
Part IV: The Adaptive Immune Response
Chapter 9: T-Cell-Mediated Immunity
Chapter 10: The Humoral Immune Response
Chapter 11: Integrated Dynamics of Innate and Adaptive Immunity
Chapter 12: The Mucosal Immune System
Part V: The Immune System in Health and Disease
Chapter 13: Failures of Host Defense Mechanisms
Chapter 14: Allergy and Allergic Diseases
Chapter 15: Autoimmunity and Transplantation
Chapter 16: Manipulation of the Immune Response
A CONSISTENT VIEWPOINT PROMOTES UNDERSTANDING
This text presents the immune system from the point of view of the host’s interaction with an environment full of microbes and pathogens. New for the Ninth Edition, the text is now organized around the concept of modular immune responses, combining innate and adaptive immunity into effector modules and explaining the integration of the innate and adaptive immune response.
UPDATED TO REFLECT THE LATEST RESEARCH ADVANCES
The pace of discovery in immunology moves fast. New or expanded coverage includes: the latest developments on innate lymphoid cells and innate sensing mechanisms, including cyclic GMP-AMP synthase (cGAS) and activation of the STING pathway, an in-depth handling of follicular helper T cells and their role in B-cell class switching and affinity maturation, cytoskeletal reorganization and integrin activation in antigen receptor signaling, expanded coverage on Akt and mTOR signaling, and more.
A DYNAMIC ART PROGRAM HELPS STUDENTS VISUALIZE IMPORTANT CONCEPTS
Students benefit from distinct and consistent iconography designed to enhance and extend the principles presented in the text. The full-color art program also features micrographs and photographs that have been thoroughly updated to include better images of protein structure and more precise micrographs, plus 100 new figures have been added.
TOOLS TO ASSESS UNDERSTANDING
End-of-chapter questions have been completely revised and include a variety of question types to help students review important concepts. Additionally, the test bank, written by Leslie Berg (University of Massachusetts Medical School), features a comprehensive set of questions to assess student understanding.