Neonatal and Pediatric Pharmacology. Therapeutic Principles in Practice

Description

Written by experts at the forefront of current research and clinical practice, Neonatal and Pediatric Pharmacology provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.

The Fourth Edition includes updated information on drug interactions and regulatory issues. New chapters cover nutrient supplements and biotransformation of medications by the human placenta.

Features

• NEW: New chapter on nutrient supplements
• NEW: New chapter on biotransformation of medications by human placenta
• NEW: Updated information on drug interactions
• NEW: Updated information on federal legislation
• Evidence-based discussion of drugs in pediatric population
• State-of-the-art discussion of what is known about the basic science of drugs in pediatrics
• Written and edited by the foremost authorities in pediatric clinical pharmacology

Table of Contents

I: GENERAL PRINCIPLES

• 1: Introduction and Historical Perspectives
• 2: Clinical Pharmacokinetics in Infants and Children
• 3: Drug Action and Therapy in the Infant and Child
• 4: Drug Metabolism and Disposition in Infants and Children
• 5: Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics
• 6: Compliance with Pediatric Medication Regimens
• 7: Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations
• 8: Ethics of Drug Research in Pediatric Populations
• 9: Therapeutic Drug Monitoring
• 10: Drug Formulations

II: DRUGS AND THE NEWBORN

• 11: Developmental Toxicology
• 12: Biotransformation of Medications by Human Placenta
• 13: Maternal Drug Intake and the Newborn
• 14: Principles of Neonatal Pharmacology
• 15: Perinatal Origins of Adult Defects in Drug Metabolism
• 16: Renal Function and Excretion of Drugs in the Newborn
• 17: The Excretion of Drugs and Chemicals in Human Milk
• 18: Drugs for Hyperbilirubinemia
• 19: Drugs and Lung Development
• 20: Pharmacologic Treatment of Neonatal Apnea
• 21: Drugs and Perinatal Brain Injury
• 22: Antiretroviral Pharmacology in Pregnant Women and Newborns

III: DRUGS IN SPECIAL POPULATIONS AND SETTINGS

• 23: Therapeutic Applications in Pediatric Intensive Care
• 24: Drug Therapy in the Pediatric Emergency Department
• 25: Drug Therapy in the Adolescent
• 26: Topical Medications
• 27: Ophthalmologic Drugs in Infants and Children

IV: SPECIFIC DRUGS

• 28: Sulfonamides
• 29: Penicillins, Cephalosporins, and Other Beta-Lactams
• 30: Aminoglycosides and Glycopeptides
• 31: Fluoroquinolones
• 32: Macrolides, Chloramphenicol, and Tetracyclines
• 33: Anthelminthic Drugs in Children
• 34: Antituberculosis Drugs
• 35: Antifungal Agents
• 36: Antiviral Drugs: Treatment of the Fetus and Newborn
• 37: Anticonvulsants
• 38: Psychopharmacology in Children and Adolescents
• 39: Antihistamine Drugs
• 40: Antiasthmatics
• 41: Antipyretics
• 42: Cardiovascular Drugs
• 43: Diuretics
• 44: Clinical Pharmacology of Antineoplastic Drugs
• 45: Immunosuppressive and Immunomodulatory Drugs
• 46: Analgesic Agents
• 47: Local Anesthetics for Infants and Children
• 48: Nonsteroidal Anti-inflammatory Drugs
• 49: Antihypertensive Agents
• 50: Gastrointestinal Drugs
• 51: Glucocorticoids
• 52: Insulin and Diabetes Mellitus
• 53: Thyroid Hormones
• 54: Growth Hormone
• 55: Hematologic Agents
• 56: Nutrient Supplements
• 57: Childhood Vaccines

V: ADVERSE DRUG EFFECTS AND INTERACTIONS

• 58: Epidemiology of Adverse Drug Effects
• 59: Mechanisms of Adverse Drug Reactions
• 60: Medication Errors
• 61: Pediatric Poisonings and Antidotes
• 62: Use of Herbal Products in Children: Risks and Unproven Benefits
• 63: Neonatal Abstinence Syndromes
• 64: Drug Interactions in Newborns and Children

VI: APPENDIX

• 65: Drug Formulary for the Newborn
• 66: Pediatric Drug Formulary