Morphology of the Blood

* covers the morphological details of both blood cells and bone marrow, with emphasis on malignant haematology * draws on theoretical knowledge and practical experience * over 500 colour slides are examined and implications explained * includes automated haematology instrument reports * clinical history, including blood film morphology and instrument, reports, are interpreted * includes morphological classification tables * ideal companion when interpreting slides at the microscope

 Morphology of the Blood pays homage to traditional morphology and emphasizes the central role of morphology in haematology even in this age of automation and molecular biology. This book has been conceived and built on the firm foundation provided by detailed morphological observation but also takes account of immunophenotypic, cytogenetic, molecular and clinical aspects of haematological disease.

The book deals with the major themes of haematological pathology bringing together classical teaching with new classification and terminology. Each illustration in this book has been derived from material obtained for diagnostic purposes from patients suffering from serious, often fatal, conditions.

Contents:

Principles of hematological cytomorphology: technical notes; anatomy and general pathology of cytomorphology; Automated methods in cytomorphological diagnosis: the three roles of automated differential counts; automated methods for differential counting of leukocytes; atypical cellular populations in automated cytochemistry; Myelodysplastic syndromes: hemocytometry and peripheral blood morphology; bone marrow morphology; non-morphological abnormalities; the FAB classification of the myelodysplastic syndromes; secondary myelodysplastic syndromes; myelodysplastic syndromes not included in the FAB classification; myelodysplasia in HIV infection; Chronic granulocytic leukemia and other myeloproliferative disorders: chronic phase; atypical chronic myeloid leukemia; accelerated phase and blast crisis; other myeloproliferative disorders; Acute myeloid leukemia: general criteria for the diagnosis and classification of the acute myeloid leukemia; acute leukemia with granulocytic differentiation; promyelocytic leukemia; acute leukemia with monocytic differentiation; erythroleukemia; megakaryocytic leukemia; acute myeloid leukemia with trilineage myelodysplasia; secondary leukemia; mixed lineage leukemia; Acute lymphoblastic leukemia: the morphological diagnosis of acute lymphoblastic leukemia; the integrated approach to the diagnosis of acute lymphoblastic leukemia; Lymphoproliferative disorders: lymphoproliferative disorders of B-lineage; B-cell non-Hodgkin's lymphoma; lymphoproliferative disorders of T-lineage; leukemic forms of T-cell lymphoma; Multiple myeloma and Waldenstrom's macroglobulinemia: multiple myeloma; plasma cell leukemia; Waldenstrom's macroglobulinemia; other plasma cell dyscrasias; The rediscovery of the reticulocyte: automated methods of reticulocyte counting; reticulocyte maturation; reticulocyte indices; reticulocyte in hematological diagnosis; Bibliography.

Readership: An atlas for those in clinical practice, diagnostic laboratories and postgraduate haematologists preparing for the FRCPath.