The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.
• First introductory textbook on subject of inflammation • Divided into six sections covering all basic aspects of inflammation, from cell types to cutting-edge animal models • Contributions by leading researchers around the world on the inflammatory response
Part I: 1. Acute inflammation and chronic inflammation Peter Ward; 2. Resolution of acute inflammation and wound healing Derek W. Gilroy; 3. Links between innate and adaptive immunity Christopher L. Karp; Part II. Individual Cell Types: 4A. Neutrophils I Jose U. Scher, Steven B. Abramson and Michael H. Pillinger; 4B. Neutrophils II Marco A. Cassatella; 5. Mast cells as sentinels of inflammation Joshua A. Boyce; 6. Basophils Jonathan Arm and David Sloane; 7. Eosinophils Sophie Fillon, Steven J. Ackerman and Glenn T. Furuta; 8. Macrophages Sarah Fox and Adriano G. Rossi; 9. Lymphocytes Tracy Hussell; 10. Fibroblasts and stromal cells Andrew Filer and Christopher D. Buckley; 11. Cell-cell interactions: PMN endothelial cells János G. Filep and Sean Colgan; Part III. Chemical Mediators: 12. Lipid mediators in acute inflammation and resolution: eicosanoids, PAF, resolvins and protectins Charles Serhan and Jesper Z. Haeggström; 13. Cytokines and chemokines / IL-1 family in inflammation Nick Lukacs; 14. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases György Haskó and Bruce Cronstein; 15. Leukocyte generation of reactive oxygen species William Nauseef; 16. Cell adhesion molecules Lucy V. Norling, Giovanni Leoni, Dianne Cooper and Mauro Perretti; Part IV. Immunopharmacology: 17. Mediators and mechanisms of inflammatory pain Tony L. Yaksh; 18. Non-steroidal anti-inflammatory drugs Roderick Flower and Samir S. Ayoub; 19. Cytokines and chemokines in inflammation cancer Thorsten Hagemann and Toby Lawrence; Part V. Inflammatory Diseases/Histology: 20. Lung Bruce D. Levy; 21. Neural inflammation, Alzheimer's disease and stroke Andrew P. Lieberman and Constance D'Amato; 22. Rheumatoid arthritis/SLE Karim Raza and Caroline Gordon; 23. Gastrointestinal inflammation and ulceration: mediators of induction and resolution Linda Vong, Paul L. Beck and John Wallace; 24. Inflammatory skin diseases Gayathri K. Perera and Frank Nestle; 25. Kidney glomerulonephritis and renal ischemia Jeremy Duffield and Joel Henderson; 26. Inflammation in cardiovascular diseases Kenneth K. Wu; Part VI. Animal Models of Inflammation: 27. Models of acute inflammation – air-pouch, peritonitis and ischemia-reperfusion André L. F. Sampaio, Neil Dufton and Mauro Perretti; 28A. Experimental models of glomerulonephritis Aidan Ryan, Denise M. Sadlier and Catherine Godson; 28B. Ischemia reperfusion injury and glomerulonephritis Jeremy Duffield; 29. Asthma Bruce D. Levy; 30. Arthritis Mike Seed; 31. Ocular inflammation models Karsten Gronert; 32. Atherosclerosis in experimental animal models Aksam Merched and Lawrence Chan; 33. Oral inflammation and periodontitis Alpdogan Kantarci, Hatice Hasturk and Thomas E. Van Dyke; 34. Pathogens and inflammation Fabiana S. Machado and Julio Aliberti; 35. Diabetes Michael J. Clare-Salzler.
Peter Ward, Derek W. Gilroy, Christopher L. Karp, Jose U. Scher, Steven B. Abramson, Michael H. Pillinger, Marco A. Cassatella, Joshua A. Boyce, Jonathan Arm, David Sloane, Sophie Fillon, Steven J. Ackerman, Glenn T. Furuta, Sarah Fox, Adriano G. Rossi, Tracy Hussell, Andrew Filer, Christopher D. Buckley, János G. Filep, Sean Colgan, Charles Serhan, Jesper Z. Haeggström, Nick Lukacs, György Haskó, Bruce Cronstein, William Nauseef, Lucy V. Norling, Giovanni Leoni, Dianne Cooper, Mauro Perretti, Tony L. Yaksh, Roderick Flower, Samir S. Ayoub, Thorsten Hagemann, Toby Lawrence, Bruce D. Levy, Andrew P. Lieberman, Constance D'Amato, Caroline Gordon, Linda Vong, Paul L. Beck, John Wallace, Gayathri K. Perera, Frank Nestle, Jeremy Duffield, Joel Henderson, Kenneth K. Wu, André L. F. Sampaio, Neil Dufton, Aidan Ryan, Denise M. Sadlier, Catherine Godson, Jeremy Duffield, Bruce D. Levy, Mike Seed, Karsten Gronert, Aksam Merched, Lawrence Chan, Alpdogan Kantarci, Hatice Hasturk, Thomas E. Van Dyke, Fabiana S. Machado, Julio Aliberti, Michael J. Clare-Salzler