The Genetic Basis of Haematological Cancers reviews the etiology and significance
of genetic and epigenetic defects that occur in malignancies of the haematopoietic
system. Some of these chromosomal and molecular aberrations are well established
and already embedded in clinical management, while many others have only recently
come to light as a result of advances in genomic technology and functional investigation.
The book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub-type. Each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. Authors then go on to discuss the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. The current or potential role of specific abnormalities as novel therapeutic targets is also discussed.
This book provides a detailed and contemporary summary of the molecular pathogenesis of haematological malignancies that would be of particular interest to students, clinicians, diagnosticians and research scientists with an interest in medical genetics and haemato-oncology.
Chapter 1: Introduction
Chapter 2: Molecular genetics of the myeloproliferative neoplasms
Philip A Beer
Chapter 3: Acute Myeloid Leukaemia
Dr Matthew L Smith and Dr Thomas McKerrell
Chapter 4: Molecular genetics of Pediatric Acute Myeloid Leukemia (AML)
MM van den Heuvel-Eibrink, JDE de Rooij, and CM Zwaan
Chapter 5: Acute Lymphoblastic Leukemia
Anna Andersson, Anthony V. Moorman, Christine J. Harrison and Charles Mullighan
Chapter 6: The Genetics of mature B-cell malignancies
Jonathan C Strefford, Jude Fitzgibbon, Matthew JJ Rose-Zerilli and Csaba Bödör
Chapter 7: The Genetics of Chronic Myelogenous Leukaemia
Philippa C May, Jamshid S Khorashad, Mary Alikian, Danilo Perrotti and Alistair G Reid