Targeted radiotherapy relies on and exploits characteristics of cancer cells to attack tumors. Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by internationally renowned experts, this book delivers a wealth of information to push future discovery.
Table of Contents
1. Antibody Engineering - Optimizing the Delivery Vehicle (Diane Milenic).
2. The Radiochemistry of Monoclonal Antibodies and Peptides (Raymond M. Reilly).
3. The Design of Radiolabeled Peptides for Targeting Malignancies (Leonard G. Luyt).
4. Peptide Receptor Radionuclide Therapy in Patients with Somatostatin Receptor-Positive Neuroendocrine Tumors (Martijn van Essen, Dik J. Kwekkeboom, Wouter W. de Herder, Lisa Bodei, Boen L.R. Kam, Marion de Jong, Roelf Valkema and Eric P. Krenning).
5. Targeted Radiotherapy of CNS Malignancies (Michael R. Zalutsky, David A. Reardon and Darrell D. Bigner).
6. Radioimmunotherapy for B-Cell Non-Hodgkin Lymphoma (Thomas E. Witzig).
7. Radioimmunotherapy of Acute Myeloid Leukemia (Todd L. Rosenblat and Joseph G. Jurcic).
8. Pre-Targeted Radioimmunotherapy of Solid Tumors (Robert M. Sharkey and David G. Goldenberg).
9. Targeted Auger Electron Radiotherapy of Malignancies (Raymond M. Reilly and Amin Kassis).
10. Viral Introduction of Receptors for Targeted Radiotherapy (Kathryn Ottolino-Perry and J. Andrea McCart).
11. Preclinical Cell and Tumor Models for Evaluating Radio-Pharmaceuticals in Oncology (Ann F. Chambers, Eva A. Turley, John Lewis and Leonard G. Luyt).
12. Radiation Biology of Targeted Radiotherapy (David Murray and Michael Weinfeld).
13. Dosimetry for Targeted Radiotherapy (Sui Shen).
14. The Bystander Effect in Targeted Radiotherapy (Carmel Mothersill and Colin Seymour).
15. The Role of Molecular Imaging in Evaluating Tumor Response to Targeted Radiotherapy (Norbert Avril).
16. The Economic Attractiveness of Targeted Radiotherapy - Value for Money (Jeffrey S. Hoch).
17. Selected Regulatory Elements in the Development of Cancer Targeted Protein and Peptide Radiotherapeutic Agents (Thomas R. Sykes and Connie J. Sykes).
RAYMOND M. REILLY is a Professor in the Leslie Dan Faculty of Pharmacy at the University of Toronto. He has more than twenty years of experience in the field of radiolabeled antibody and peptide targeting of cancer. Dr. Reilly has written over 180 publications in the field, including more than 100 scientific papers on radiopharmaceuticals for cancer imaging and targeted radiotherapy.