With a foreword by John T. Queenan, MD, Professor and Chair Emeritus of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington. Fetal medicine has emerged as a separate subspecialty over the last 30 years as a result of major advances in a number of areas, in particular ultrasound imaging, cytogenetics, molecular biology and biochemistry. The widespread use of antenatal screening and diagnostic tests has led to an increased need for obstetricians to have knowledge and skills in fetal medicine. This book provides the information that underpins training programmes in fetal medicine and integrates science and clinical disciplines in a practical and useful way.
- Basic science sections provide clinicians with a vital introduction to the new language of science that will help them understand new and development treatment options.
- Clinical sections include: the latest advances in prenatal screening; a systems-based presentation of the diagnosis and management of fetal malformations; complete coverage of common and rare fetal conditions including growth restriction, endocrine and platelet disorders, early pregnancy loss, and twins/multiple pregnancy.
- Highly illustrated with over 500 ultrasound scans and line drawings.
- International team of expert contributors.
- Features new self-assessment section.
- Written by an international team of experts.
New to this Edition
- Shorter, more focused on fetal medicine
- Clinical sections written in an up-to-date, problem-based style
- Case studies and vignettes to illustrate clinical points
- More focus on important basic-science concepts, such as maternofetal cell trafficking, and the relevance to clinical management
- Expansion of information on bereavement due to fetal loss
- New self-assessment section
Table of Contents
EARLY FETAL DEVELOPMENT
1. Early concepts and terminology 2. Cellular mechanisms and embryonic tissues 3. Staging embryos in development and the embryonic body plan 4. Development of the head 5. Development of the heart
6. The immunology of implantation 7. Development of the placenta and its circulation 8. Placental function and maternofetal exchange 9. Maternofetal trafficking
FETAL PHYSIOLOGY AND PATHOLOGY
10. Development of the cardiovascular system 11. Lung growth and maturation 12. Development of the kidneys and urinary tract 13. Maternal medicines and the fetus 14. The perinatal postmortem
15. Epidemiological techniques in fetal medicine.
16. Ethical issues in maternal-fetal medicine
PRENATAL SCREENING AND DIAGNOSIS
17. Conveying information about screening 18. Parental reaction to prenatal diagnosis and subsequent bereavement 19. Prenatal screening for open neural tube defects and Down's syndrome 20. Ultrasound screening for fetal abnormalities and aneuploidies in the first and second trimesters 21. Non-invasive screening and diagnosis from maternal blood 22. Invasive diagnostic procedures 23. Cytogenetics 24. Mandelian genetics - the old and the new 25. Preimplantation genetic diagnosis 26. Haemaglobinopathies 27. Prenatal screening for thalassemias 28. Cystic fibrosis 29. Inborn errors of metabolism
DIAGNOSIS AND MANAGEMENT OF FETAL MALFORMATIONS
30. Sonography of the fetal central nervous system 31. The heart 32. Fetal lung lesions 33. Congenital diaphragmatic hernia 34. Abdomen 35. Kidney and urinary tract disorders 36. Fetal skeletal abnormalities 37. Fetal hydrops 38. Fetal tumors
DIAGNOSIS AND MANAGEMENT OF OTHER FETAL CONDITIONS
39. Fetal growth and growth restriction 40. Red cell alloimmunization 41. Fetal platelet disorders 42. Treatable fetal endocrine and metabolic disorders 43. Early pregnancy failure 44. Fetal infections 45. Amniotic fluid 46. Multiple pregnancy 47. In utero stem cell transplantation 48. Fetal gene therapy
49. Interface of fetal and neonatal medicine
Self-assessment scenarios Appendix: Charts of fetal measurements Index
By Charles H. Rodeck, MB, BS, BSc, DSc, FRCOG, FRCPath, FMedSci, Emeritus Professor, Institute for Women's Health, Obstetrics and Gynaecology, University College London, London, UK; and Martin J. Whittle, MD, FRCOG, FRCP(Glas), Emeritus Professor of Fetal Medicine, University of Birmingham, Birmingham, UK