This book provides a definitive reference work on the developing brain, from conception through the first year of life. Its purpose is to provide the range of specialists involved in the management of the fetus and the neonate with the latest information on the developmental neurology and pathology of the developing central nervous system, so that they can provide prompt and informed treatment of neurological disability – the most feared complication of pregnancy and the early months of the life of the newborn child.
- A cross-specialty book: brings together the work of specialists on the immature brain from the fields of obstetrics, paediatrics and neurosurgery.
- An international book: edited and written by an international team of experts.
- Highly illustrated: includes over 800 images and line drawings that capture the latest investigative techniques.
- Focused on treatment: key points boxes pick out the most important information for the busy specialist.
- Evidence-based information: extensively referenced with the latest and most important papers and articles.
New to this Edition
- Includes the latest ultrasound techniques – to reflect the massive improvements since the last edition.
- Medico-legal issues highlighted – in recognition of the role of specialists as expert witnesses.
- Covers the latest MR techniques: fast sequences for fetal brain imaging, DWI, tractography.
Table of Contents
SECTION I Structural Development of the CNS
1. The molecular basis of brain development 2. Early embryonic development of the brain 3. Development of consciousness: fetal, neonatal and maternal interactions 4. Ultrasound assessment of normal fetal brain development 5. MR imaging of the fetal central nervous system 6. Imaging the neonatal brain
SECTION II Functional Assessment of CNS Development
7. Functional assessment of the fetal CNS 8. The development of senses 9. Clinical assessment of the infant nervous system 10. Perinatal cerebral circulation 11. Cerebral blood flow and energy metabolism in the developing brain 12. EEG and evoked potentials in the neonatal period
SECTION III Anomalies
13. Congenital structural defects of the brain 14. Genetics of neurodevelopmental anomalies 15. Antenatal assessment of CNS anomalies, including neural tube defects 16. Transvaginal fetal neuroscan< 17. Epidemiology and prevention of neural tube defects
SECTION IV Hemorrhagic and Ischemic Lesions
18. Fetal brain injury and multiple pregnancies 19. Infection, inflammation and brain injury 20. Neonatal intracranial hemorrhage 21. Cerebral ischemic lesions
SECTION V Perinatal Asphyxia
22. Pathophysiology of asphyxia 23. Antenatal prediction of asphyxia 24. Intrapartum monitoring for asphyxia 25. Prediction of asphyxia with fetal gas analysis 26. The asphyxiated newborn infant 27. Neuroprotection of the fetal and neonatal brain 28. Medico-legal issues: The United Kingdom perspective 29. Malpractice issues in perinatal medicine: The United States perspective
SECTION VI Infection of the CNS
30. Toxoplasmosis 31. Congenital viral infections and the central nervous system 32. Bacterial and fungal infections
SECTION VII Metabolic Disorders
33. Inborn errors of metabolism presenting with encephalopathy
SECTION VIII Seizure Disorders
34. Seizure disorders of the neonate 35. Hypoglycemia and brain injury - when neonatal metabolic adaptation fails 36. Kernicterus
SECTION IX the Special Senses
37. Disorders of vision 38. Hearing disorders
SECTION X Disorders of the Nerve and Muscle
39. Disorders of the spinal cord, cranial and peripheral nerves 40. Neuromuscular disorders
SECTION XI Hydrocephalus and Neurosurgery
41. Fetal neurosurgical interventions 42. Neonatal hydrocephalus – clinical assessment and non-surgical treatment 43. Neurosurgical management of hydrocephalus 44. Surgical management of neural tube defects 45. Congenital defects, vascular malformations and other lesions
SECTION XII Epidemiology of Neurologic Disability
46. The epidemiology of the cerebral palsies 47. The epidemiology of intellectual disabilities
SECTION XIII Ethical Dilemmas
48. Issues for the obstetrician 49. Issues for the neonatologist
By Malcolm I. Levene, MD, FRCP, FRCPCH, FMedSc, Professor of Pediatrics and Child Health, Division of Paediatrics and Child Health, University of Leeds, Leeds General Infirmary, Leeds, UK; and Frank A. Chervenak, MD, FACOG, MMM, Given Foundation Professor and Chairman, Department of Obstetrics and Gynecology, New York Weill Cornell Medical Center, New York, NY, USA