Cardiac aging, like aging in general, is a complex process. Numerous cellular and molecular changes contribute to the expression of the multiple phenotypes of aging, "the different faces" of cardiac aging. In this book, the genetic and molecular basis of cardiovascular aging will be discussed. In addition, a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities will be undertaken.
José Marín-García is Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, New Jersey.
Cardiologists, cardiovascular researchers, libraries
Table of contents
Preface.- Section I. Introduction to A Post-Genomic View of Aging and the Aging Heart: Post-Genomic View of Aging: Definitions, Theories and Observations.- Overview of Cardiovascular Aging.- Section II. Methodologies, Cardiac Phenotypes And Adaptation: Molecular and Cellular Methodologies.- Molecular And Cellular Phenotypes of Cardiac Aging.- Section III. Aging of the Cardiovasculature and Related Systems: Aging of the Vasculature.- Aging of Cardiovascular-Related Systems.- Section IV. Cardiovascular Diseases in Aging: Cardiomyopathy and Heart Failure in Aging.- Atherosclerosis, Hypertension and Aging.- Metabolic Syndrome, Diabetes and Cardiometabolic Risks in Aging.- Gender and Cardiovascular Aging.- Cardiac Dysrhythmias and Channelopathies in Aging.- Section V. Genetics: Genetics of Life Span: Lessons from Model Organisms.- Profiling the Aging Cardiovascular System: Transcriptional, Proteomic, SNP, Gene Mapping and Epigenetics Analysis.- Section VI. Therapies: Translational Research: Pharmacogenomics, Gene and Cell-Based Therapy in the Aging Cardiovascular System.- Nutrition and Exercise in Cardiovascular Aging: Metabolic and Pharmacological Interventions.- Section VII. The Future of Aging Research: Aging and the Frontier ahead.- Glossary.- Index.