Cancer Metastasis and the Lymphovascular System. Basis for Rational Th

Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process.

· Molecular imaging advances help to localize early cancers more precisely.

· Current status of the immune responses in the draining lymph nodes against cancer is summarized.

· New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment.

In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.

Series editor's comments:

"Cancer metastasis remains the greatest challenge for oncologists. The role of the lymphovascular system is critical and a focus of intense investigations. This text covers a spectrum of relevant research and clinical issues that impact on our understanding of this process."

Steven T. Rosen, MD

Series Editor

Written for:

Basic clinicians and scientists interested in cancer metastasis and the lymphovascular system

Keywords:

lymphovascular

metastasis

Table of contents

Landmarks and Advances in Translational Lymphology.-

Embryonic Development of the Lymphovascular System and Tumor Lymphangiogenesis.-

Lymphatic Origin from Embryonic Stem Cells.-

Lymphatic Markers, Tumor Lymphatics and Tumor Lymphangiogenesis.-

Anatomy of the Human Lymphatic System.-

SPECT-CT Fusion Imaging Radionuclide Lymphoscintigraphy: Potential for Limb Lymphedema Assessment and Sentinel Node Detection in Breast Cancer.-

Sentinel Node Identification Using Radionuclides in Melanoma and Breast Cancer.-

Targeted Introduction of Substances into the Lymph Nodes for Endolymphatic Therapy.-

"Seed and Soil" Mechanisms of Metastasis.-

Preclinical Models of Regional Lymph Node Tumor Metastasis.-

Lymph Node Micrometastasis in Lung Cancer.-

Effect of Chemokines on Tumor Metastasis.- Regional Lymph Node Metastases, a Singular Manifestation of the Process of Clinical Metastases in Cancer.-

Patterns of Metastasis in Head and Neck Cancer.-

Patterns of Metastasis in Human Solid Cancers.-

Significance of Regional Draining Lymph Nodes in the Development of Tumor Immunity: Implications for Cancer Immunotherapy.-

Targeting Small Molecules in Cancer.-

Update on the Role of EGFR Inhibitors in Cancer.-

New Promises in the Adjuvant, Neoadjuvant and Palliative Treatment of Melanoma.-

Future Perspectives and Unanswered Questions on Cancer Metastasis and the Lymphovascular System.