Presents a comprehensive overview of different mechanisms of immune dysfunction
Discusses a number of new mechanisms that have never been discussed in a monograph report including: T-cell inhibitory molecules and regulatory tolergenic DCs
Focus on therapeutic correction of the observed abnormalities
Tumor Induced Immune Suppression: Mechanisms and Therapeutic Reversal focuses on the critical question of tumor biology: "Why can tumors escape immune system control?" It also addresses one of the most important problems within the field of clinical oncology: the lack of efficient cancer vaccines. Edited by Dmitry Gabrilovich and Andy Hurwitz, the book is the first attempt at a systematic and comprehensive analysis of the various immunosuppressive mechanisms in cancer. This analysis includes information on:
Different surface molecules that mediate T-cell suppression in cancer;
The specific roles of dendritic cells, macrophages, and myeloid-derived suppressor cells in tumor non-responsiveness;
The contribution of regulatory T cells in the inability of immune systems to mount antitumor response;
The role of T-cell signaling and different metabolic pathways in tumor-associated immune suppression.
This volume connects a multitude of different immunosuppressive mechanisms into one cohesive picture. Most of the chapters not only describe the biological phenomena, but also suggest specific approaches to their correction.
This book should be of high interest for researchers in the fields of tumor immunology and general immunology, as well as for those who are involved in clinical oncology and cancer immunotherapy.
Basic scientists working in the field of tumor immunology, T-cell activation, antigen presenting cells, and cytokines. Basic scientists and physicians working in the field of cancer immunotherapy and cancer vaccines, medical oncologists, graduate students in Immunology and Cancer Biology Programs
- Dendritic Cells
- Immune Suppressive Mechanisms
- T Cell
- Tumor Development
- inhibitory pathway
Table of contents
Introduction.- Mechanisms and Therapeutic Reversal of the Defects in T-Cell Function in Cancer.- Molecular Mechanisms of Tumor-Associated T-Cell Tolerance.- T-Cell Tolerance.- T-Cell Inhibitory Molecules and Suppression of T-Cell Function In Cancer.- CTLA-4 and T-Cell Tolerance in Cancer.- Regulatory T-Cells in Cancer.- T-Cell Apoptosis in Cancer.- Defects in Dendritic Cell Differentiation in Cancer and Tumor Escape.- Dendritic Cells With Tolerogenic Potential in Cancer.- Signaling Pathways in Antigen-Presenting Cells Involved in Induction of T-Cell Tolerance.- Macrophages and Tumor Development.- Immature Myeloid Suppressor Cells in Tumor-Induced T-Cell Tolerance.- Arginin Metabolism as A Critical Element of Tumor Suppression in Cancer.- Role of Reactive Oxygen Species in T-Cell Defects in Cancer.- Cytokine Production in Cancer and their Negative Effect on Immune Response.- Inflammation and Immune Abnormalities in Cancer.- Tumor Stroma and Antitumor Immune Response.- Tumor Associated Immune Defects. Where are Now and Where are We Going.