Stroke. Pathophysiology, Diagnosis, and Management

Description

Offered in print, online, and downloadable formats, this updated edition of Stroke: Pathophysiology, Diagnosis, and Management delivers convenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors - Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong - head the sixth edition of this classic text, which is authored by the world’s foremost stroke experts.

New to this edition

• Comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy.
• Brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke.
• New information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design.
• Advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography.
• Extracted and highlighted evidence levels.
• Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded to tablets and smart phones for offline use.

Contents

SECTION I: Pathophysiology

• 1 Vascular Biology and Atherosclerosis of Cerebral Vessels
• 2 Mechanisms of Thrombosis and Thrombolysis
• 3 Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease
• 4 Histopathology of Brain Tissue Response to Stroke and Injury
• 5 Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death
• 6 Intracellular Signaling: Mediators and Protective Responses
• 7 The Neurovascular Unit and Responses to Ischemia
• 8 Mechanisms of Cerebral Hemorrhage
• 9 White Matter Pathophysiology
• 10 Inflammation and Immune Response
• 11 Mechanisms of Plasticity, Remodeling and Recovery
• 12 Genetics and Vascular Biology of Angiogenesis and Vascular Malformations

SECTION II: Epidemiology and Risk Factors

• 13 Global Burden of Stroke
• 14 Stroke Disparities
• 15 Modifiable Risk Factors and Determinants of Stroke
• 16 Prognosis after Stroke
• 17 Vascular Dementia and Cognitive Impairment
• 18 Genetic Basis of Stroke Occurrence, Prevention and Outcome
• 19 Preventing a First Stroke

SECTION III: Clinical Manifestations 20 Classification of Ischemic Stroke

• 21 Clinical Scales to Assess Patients with Stroke
• 22 Carotid Artery Disease
• 23 Anterior Cerebral Artery Disease
• 24 Middle Cerebral Artery Disease
• 25 Posterior Cerebral Artery Disease
• 26 Vertebrobasilar Disease
• 27 Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small Vessel Disease
• 28 Intracerebral Hemorrhage
• 29 Aneurysmal Subarachnoid Hemorrhage
• 30 Arteriovenous Malformations and Other Vascular Anomalies
• 31 Stroke and Other Vascular Syndromes of the spinal Cord

SECTION IV: Specific Conditions and Stroke

• 32 Cardiac Diseases
• 33 Atherosclerotic Disease of the Proximal Aorta
• 34 Stroke Related to Surgery and Other Procedures
• 35 Arterial Dissections and Fibromuscular Dysplasia
• 36 Collagen Vascular and Infectious Diseases
• 37 Reversible Cerebral Vasoconstriction Syndromes
• 38 Hypertensive Encephalopathy
• 39 Stroke and Substance Abuse
• 40 Moyamoya Disease
• 41 CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
• 42 Hematologic Disorders and Stroke
• 43 Migraine and Stroke
• 44 Cryptogenic Stroke
• 45 Cerebral Venous Thrombosis

SECTION V: Diagnostic Studies

• 46 Ultrasonography
• 47 Computed Tomography-based Evaluation of Cerebrovascular Disease
• 48 Magnetic Resonance Imaging of Cerebrovascular Diseases
• 49 Cerebral Angiography

SECTION VI: Therapy

Part A: Medical Therapy

• 50 Prehospital and Emergency Department Care of the Patient with Acute Stroke
• 51 Intravenous Thrombolysis
• 52 Antithrombotic Therapy for Treatment of Acute Ischemic Stroke
• 53 General Stroke Management and Stroke Units
• 54 Critical Care of the Patient with Acute Stroke
• 55 Pharmacologic Modification of Acute Cerebral Ischemia
• 56 Treatment of "Other" Stroke Etiologies
• 57 Medical Therapy of Intracerebral and Intraventricular Hemorrhage
• 58 Rehabilitation and Recovery of the Patient with Stroke
• 59 Interventions to Improve Recovery after Stroke
• 60 Enhancing Stroke Recovery with Cellular Therapies
• 61 Antiplatelet Therapy for Secondary Prevention of Stroke
• 62 Secondary Prevention of Cardioembolic Stroke
• 63 Conduct of Stroke-Related Clinical Trials

Part B: Interventional Therapy

• 64 Endovascular Therapy of Extracranial and Intracranial Occlusive Disease
• 65 Endovascular Treatment of Acute Ischemic Stroke
• 66 Endovascular Treatment of Cerebral Aneurysms
• 67 Interventional Therapy of Brain and Spinal Arteriovenous Malformations
• 68 Dural Arteriovenous Malformations

Part C: Surgical Therapy

• 69 Surgery of Anterior and Posterior Aneurysms
• 70 Surgery for Intracerebral Hemorrhage
• 71 Intraventricular Hemorrhage
• 72 Surgical Management of Cranial and Spinal Arteriovenous Malformations
• 73 Surgical Cavernous Malformations and Venous Anomalies
• 74 Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis
• 75 Extracranial to Intracranial Bypass for Cerebral Ischemia
• 76 Decompressive Craniectomy for Infarction and Hemorrhage

Authors

By James C. Grotta, MD, Director, Stroke Program, Memorial Hermann - Texas Medical Center; Professor of Neurology; Chairman, Department of Neurology, University of Texas Medical School at Houston, Houston, TX, USA.; Gregory W Albers, MD, Director, Stanford Stroke Center; Coyote Foundation Professor of Neurology and Neurological Sciences ; Joseph P Broderick, MD, Director of the Greater Cincinnati-Northern Kentucky Stroke Team; Professor and Chairman, University of Cincinnati, Department of Neurology and Rehabilitation Medicine, Cincinnati, OH ; Scott E Kasner, MD, MSCE, FRCP, Professor of Neurology at the Hospital of the University of Pennsylvania, Philadelphia, PA; Eng H Lo, PhD, Professor of Neuroscience, Harvard Medical School; Head, Neuroprotection Research Lab, Massachusetts General Hospital, Charlestown, MA ; A David Mendelow, MB BCh, FRCS, PhD, William Leech Professor of Neurosurgery, Newcastle University, UK ; Ralph L Sacco, MD MS FAHA FAAN, Olemberg Chair of Neurology and Professor of Neurology, Epidemiology and Public Health, Human Genetics, and Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL and Lawrence KS Wong, MD, FRCP, Mok Hing Yiu Professor of Medicine, Chief of Neurology, Departments of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, PR China