This comprehensive reference addresses all aspects of fetal and neonatal pathology, including complicated pregnancies, multiple pregnancies, abortion, placental pathology, and disorders affecting the full-term neonate. A consistent organization allows for quick access to specific guidance, and nearly 2,500 illustrations - 2,350 in full color - depict conditions and abnormalities as they present in practice, facilitating diagnosis. An Image Bank on CD-ROM - new to this edition - features all of the illustrations from the 2-volume set, downloadable for presentations.
"Should appeal to every pathologist who deals with the disorders and deformities of early life." -- Pediatric and Developmental Pathology, 2007 "The presentation is spectacular. 2,350 (94%) of the illustrations are in color, and most are of excellent quality." -- Pediatric and Developmental Pathology, 2007 "This is a work that pleases the eye, feeds the mind and tones the arm muscles.... So get out that credit card, bulk up those biceps, reinforce your bookshelves and add these lovely and generally excellent volumes to your departmental or personal library." -- Pediatric and Developmental Pathology, 2007
* Offers comprehensive coverage of all common and rare embryonic, fetal, and infant disorders in one source.
* Correlates clinical, pathologic, and genetic findings for each systemic disease.
* Emphasizes the genetic and molecular basis of birth defects. Features nearly 2,500 illustrations - 2,350 in full color - which depict each abnormality or condition as they present in practice.
* Presents practical information on autopsy techniques and protocols.
New to this Edition
* Provides the latest guidance on molecular pathology, immunohistochemistry,
DNA technology, and more.
* Offers an expanded discussion of developmental biology related to the pathogenesis of birth defects.
* Features user-friendly summary tables and diagnostic flow charts, making information quick and easy to find.
* Includes a CD-ROM featuring all of the illustrations from the 2-volume set.
Part 1 Genetic and Developmental Pathology
1. Mechanisms of Development and Growth: Molecular Genetics
2. Causes and Pathogenesis of Birth Defects
3. Abnormalities of Blastogenesis, Organogenesis, and Phenogenesis
4. Pathology of Abortion: The Embryo and the Previable Fetus
5. Causes of Stillbirth and Neonatal Death
6. Prenatal Diagnosis
7. Pathology of the Placenta
8. Multiple Pregnancies and Conjoined Twins
I. Teratogenic Disruptions
II. Vascular Disruptions
10. Chromosomal Abnormalities
11. Sudden Death in Infants:
I. Sudden and Unexpected Death in Infants
II. Mechanisms of the Sudden Infant Death Syndrome
12. Complications of Perinatal Care
Part 2 Systematic Pathology
13. Perinatal, Fetal, and Embryonic Autopsy
14. Infectious Diseases
15. Nutritional Diseases
16. Metabolic Diseases
17. Cardiovascular System:
I. Development of the Heart and Congenital Malformations
II. Cardiovascular Disorders
18. Respiratory System
19. Gastrointestinal Tract and Pancreas
20. Liver, Gallbladder, and Biliary Tract
21. Renal System:
I. Kidneys and Urinary Tract
II. Genetic Disorders and Malformation Syndromes
22. Hematopoietic System:
I. Bone Marrow and Peripheral Blood
II. Coagulation Disorders
23. Thymus, Spleen, Lymphoid, Tissues, and Immunodeficiency Disorders
24. Central Nervous System:
III. Fetal and Neonatal Brain Damage
IV. The “At-Risk” Fetus
25. Endocrine Glands
26. Reproductive System
27. Soft Tissue Tumors
28. Skin Diseases
29. Neuromuscular Diseases
30. Skeletal System:
I. Osteochondrodysplasias and Dysostoses
31. The Eye
32. Head and Neck:
I. Craniofacial Abnormalities
II. Salivary Glands
33. Pediatric Forensic Pathology
Edited by Enid Gilbert-Barness, AO, MD, FRCPA, FRCPath, DSci(hc), MD(hc), Professor of Pathology, Laboratory Medicine and Pediatrics, Department of Pathology, Tampa General Hospital, Tampa, FL, USA; Raj P. Kapur, MD, PhD, Associate Professor, Department of Pathology, University of Washington, Seattle, WA, USA; Luc Laurier Oligny, MSc, MD, Associate Professor, Department of Pathology and Cellular Biology, University of Montreal, Montreal, Quebec, Canada; and Joseph R. Siebert, PHD, Research Associate, Professor of Pathology, Children's Hospital and Regional Medical Center, Seattle, WA