- Provides critical information relevant to everyday practice, reflecting the way hematology is practiced today.
- Covers basic science only as it relates to clinical practice.
- Utilizes full-color photographs, illustrations, and functional drawings to highlight critical information and difficult concepts.
- Uses consistent, templated chapters to make essential information uncommonly easy to find.
- Offers a unique approach by innovative experts in the field.
- Includes a CD-ROM containing all of the book’s figures, tables, algorithms, and charts all downloadable for PowerPoint® presentations, as well as a comprehensive reference library.
I. Basic Science of Hematology
* Hematopoiesis (including cytokines) * Globin/Heme * Erythrocyte structure * Red cell antigens * Granulocyte biology * Lymphocyte biology (including Ig) * Megakaryocytes and platelets * Coagulation factors * Vascular biology
II. Hematologic Diseases
Section 1. Diseases of Hematopoietic Cell Production
* Marrow failure * Acquired aplastic anemia * Fanconi anemia and dyskeratosis congenital * Pure red cell aplasia * Myelodysplastic syndromes * Hairy cell leukemia * Large granular lymphocytic leukemia * Mineral and vitamin deficiencies * Iron deficiency * Pernicious anemia and folate deficiency * Anemia of chronic disease
Section 2. Diseases of blood cell destruction
* Hemolytic anemias * Inherited HA * Sickle cell disease and other hemoglobinopathies * Thalassemias * Hereditary spherocytosis * RBC enzymopathies * Acquired HA * Autoimmune HA * Paroxysmal nocturnal hemoglobinuria * Mechanical HA * Immune thrombocytopenias * ITP, PTP, neonatal TP * Drug-induced thrombocytopenia * Heparin-induced thrombocytopenia * TTP and HUS * Neutropenias * Kostmann's and other onstitutional neutropenias * Agranulocytosis, pure white cell aplasia
Section 3. Malignant and proliferative hematologic diseases
* Leukemias * Leukemias: diagnosis and classifications * Acute myelogenous leukemia * Secondary MDS/AML * Chronic myelogenous and myelomonocytic leukemia * Acute lymphocytic leukemia * Pediatric leukemias * Chronic lymphocytic leukemia * Myeloproliferative diseases * Polycythemia vera and essential thrombocytosis * Myelofibrosis * Hypereosinophilia * Lymphomas and lymphoid malignancies * Biology of lymphoid malignancy * Hodgkins disease * Cutaneous lymphomas * CNS lymphomas * NonHodgkins lymphomas * Infectious malignancies * HIV-1 and HTLV-1-associated lymphomas * EBV, HHV-8 * Cryoglobulinemia * Multiple myeloma * MGUS * Macroglobulinemia * Histiocytosis * Amyloidosis * Mastocytosis * Diseases of the spleen
Section 4. Inherited and Acquired Metabolic Blood Diseases
* Porphyrias * Hemochromatosis * Familial Mediterranean fever * ALPS
Section 5. Diseases of Altered Coagulation Bleeding Disorders
* Platelet diseases * Inherited and acquired platelet disorders * von Willebrands disease * Coagulation factor disorders * Hemophilias (F VIII and IX deficiencies) * Acquired inhibitors * Thrombotic disorders * Inherited deficiencies of proteins C, S; factor V * Leiden * Anti-phospholipid syndrome * Heparin-induced thrombocytopenia
III. Consultative Hematology
Section 1. Hematology of Growth, Development, and Aging
* Hematologic complications of pregnancy * Hematology of the newborn * Pediatric hematology * Geriatric hematology
Section 2. Infections of Marrow and Blood Viruses
* Epstein-Barr virus * CMV * HHV-8 and other herpesviruses * Parvovirus B19 * HIV-1 and the hematology of AIDS * Hepatitis C * Dengue and hemorrhagic fever viruses * Protozoa * Malaria * Bartonellosis and others * Parasites * Hookworm
Section 3. Hematologic Problems of Medical Practice Anemia
* Hematologic drug reactions * Erythrocytosis * Kidney disease * Liver disease * Chronic bruising and the bleeding diathesis evaluation * Venous and arterial thrombosis * Anticoagulant therapy * Disseminated intravascular coagulation * Chemotherapy toxicities and complications
Section 4. Hematologic Complications in Surgery
* Evaluation of the acutely bleeding patient * Surgery in specific hematologic conditions
IV. Tools for the Hematologist
Section 1. Specialized practice
* HLA and Transplantation of Unrelated Cells * Marrow and blood transplantation * Supportive care during transplantation * Graft-versus-host disease * Transfusion medicine * Practice of blood component transfusion * Complications of transfusion (incl hepatitis, 2o iron overload)
Section 2. Laboratory methods
* Blood and marrow morphology (incl histochemistry) * Flow cytometry * Cytogenetics/FISH * DNA/functional genomics * Coagulation testing