- Presents a thorough examination of the unifying principles from the subcellular to the systems and clinical levels;
- Identifies common themes among molecular biology, genetics, physiology, pathology, biomarkers, behavior, and treatment strategies that are shared between neurodegenerative diseases;
- Enables better care of patients and help build collaboration across researchers in multiple specializations that could help advance future insights and facilitate novel therapies and enhancing basic scientific understanding of these diseases to a new generation.
As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research.
Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.
This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.
Table of Contents
List of Contributors
1 Neurodegenerative Diseases: Evolving Unifying Principles
Jeffrey Cummings and Jagan Pillai
2 Neurodegenerative Diseases as Protein Misfolding Disorders
Tomohiro Nakamura and Stuart A. Lipton
3 Calcium Hypothesis on Neurodegeneration: The Case of AD and HD
Daniel A. Ryskamp, Elena Popugaeva, and Ilya Bezprozvanny
4 Neuroinflammation and Neurodegenerative Diseases
Taylor R. Jay, Shane M. Bemiller, Lee E. Neilson, Paul J. Cheng, and Bruce T. Lamb
5 Prion Paradigm of Human Neurodegenerative Diseases Caused by Protein Misfolding
6 Neuropsychiatric Features Across Neurodegenerative Diseases
Claudia R. Padilla and Mario F. Mendez
7 Brain Circuits: Pathway for NDD
8 Fluid Biomarkers Indicative of Neurodegenerative Diseases
Henrik Zetterberg and Jonathan M. Schott
9 Predementia Disorders: Neurodegenerative Diseases Predecessor States as Unifying Clinical Features
10 Genetics of Neurodegenerative Diseases: Sporadic and Autosomal Dominant Forms
Lynn M. Bekris and James B. Leverenz
11 An Epigenetics Perspective on Diseases of the Central Nervous System
12 Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases
Andrew B. Knot and Ella Bossy-Wetzel
13 Cell Culture and iPS Cells and Neurodegenerative Diseases
Roxana Nat and Andreas Eigentler
14 Animal Models of Neurodegenerative Diseases
David Baglietto-Vargas, Rahasson R. Ager, Rodrigo Medeiros, and Frank M. LaFerla
15 Metal-Protein Attenuating Compounds in Neurodegenerative Diseases
Peng Lei, Scott Ayton, and Ashley I. Bush
16 Disease modifying therapies in neurodegenerative disorders
Janelle Drouin-Ouellet and Roger A. Barker
17 Immunotherapy for Neurodegenerative Disorders
18 Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles
Jeffrey Cummings and Kate Zhong
19 Conclusions on Neurodegenerative Disorders: Unifying Principles
Jagan Pillai and Jeffrey Cummings
Edited by Jeffrey L. Cummings, MD, ScD, Director, Cleveland Clinic, Lou Ruvo Centre for Brain Health, Las Vegas, Nevada, and Edited by Jagan A. Pillai, MBBS, PhD, Director, Cleveland Clinic, Lou Ruvo Centre for Brain Health, Cleveland, Ohio
Dr. Jeffery Cummings is an internationally recognized leader in clinical trials and drug development for neurodegenerative disorders. His work has been features in major peer-reviewed journals and his books have been influential world-wide. His work has garnered many awards.
Dr. Jagan Pillai trained as a medical doctor at the University of Kerala, Trivandrum, India, obtained his PhD from Northwestern University, and pursued Residency in Neurology at the Albert Einstein College of Medicine. Dr. Pillai was closely involved in helping people with memory disorders and cognitive behavioral changes from neurodegenerative diseases. As a young scholar, Dr. Pillai further developed in research in Alzheimer's dementia and Huntington's disease. Dr. Pillai joined the Lou Ruvo Center for Brain Health in January 2012. He now works to help people with cognitive changes from neurological disorders and to develop diagnostic and treatment strategies for people with cognitive difficulties from neurodegenerative diseases.