For senior-level and first-year graduate courses in Tissue Engineering, in departments of bioengineering; and for students researching tissue replacement and restorations; as well as students of biology medicine and life science working with primary and complex cell biology.
This text—the first in its field—lays the foundation for students studying tissue engineering. It provides a conceptual framework that includes exposure to all the necessary background material in all areas.
- Coverage of basic, important fundamental concepts—Rather than review
o Makes this book a practical guide in the field as tissue engineering changes, and helps students establish a conceptual framework within which to place further advances in the field.
- A four-part presentation—Part I quantitative cell and tissue biology;
Part IIcell and tissue characterization; Part IIIengineering methods and design;
and Part IVclinical implementation.
o Supplies students with the broad coverage that eliminates their need to supplement class notes with medical and methods literature.
- Emphasis on relevant time and length scales of physical-chemical processes
in cell biology and medicine.
o Establishes a conceptual framework within which to place further advances in the field.
- Broad range of quantitative homework sets with solutions.
o Gives students extensive opportunity to apply learned concepts throughout the text.
TABLE OF CONTENTS
I. QUANTITATIVE CELL AND TISSUE BIOLOGY.
2. Tissue Organization.
3. Tissue Dynamics.
5. Stem Cells.
6. The Cellular Fate Processes.
II. CELL AND TISSUE CHARACTERIZATION.
8. High-Throughput Biological Data.
9. Cell and Tissue properties.
10. Cell and Tissue Culture.
11. Gene Transfer.
III. ENGINEERING METHODS AND DESIGN.
12. Time Constants.
14. Cell Separation.
15. Biomaterial Scaffolds.
16. Tailoring Biomaterials.
IV. CLINICAL IMPLEMENTATION.
17. Conventional Approaches to Tissue Repair.
18. Host Integration.
19. Producing TE Therapies.
Tissue Engineering Study Problems.
Tissue Engineering (Bioengineering)
Tissue engineering is a complex and emerging field of study that combines basis biological sciences (molecular, cell, and tissue biology and physiology), engineering fundamentals (fluid mechanics, transport phenomena, materials science, chemical kinetics), clinical aspects (surgery, transplantation, immunology, pathology, radiology) and biotechnology (cell culture, cell separations, gene transfer). All these disciplines converge to study of tissue dynamics that coordinate tissue repair, replacement, and reconstruction. These are procedures and therapies in which cells themselves act as the therapeutic agents.
This book on tissue engineering is the first textbook in this field and it offers the convergence of important fundamental concepts in biology, engineering, medicine, and biotechnology. These diverse concepts are carefully organized and laid out in a clear framework to orient students entering the field. This framework includes four parts:
· Part I: Quantitative Cell and Tissue Biology—Including tissue organization, tissue dynamics, morphogenesis, stem cells, cellular fate processes, and their coordination.
· Part II: Cell and Tissue Characterization-Including high-throughput technologies, cell and tissue properties, cell and tissue culture, and gene transfer
· Part III: Engineering Methods and Design-Including time constant analysis, scale-up procedures, cell separations, biomaterial scaffolds, and how to tailor biomaterials
· Part IV: Clinical Implementation-Including conventional approaches to tissue repair, host integration, and producing tissue-engineered therapies.
This book thus offers the basics of this emerging field to the student and a framework in which instructors can build comprehensive courses, with the flexibility to emphasize and expand on any particular topic.