1. Introduction to Virus Origins and Their Role in Biological Evolution
2. Molecular Basis of Genetic Variation of Viruses
3. Darwinian Principles Acting on Highly Mutable Viruses
4. Dynamics of Virus Populations and Their Hosts
5. Viral Fitness as a Measure of Adaptation
6. Virus Population Dynamics Examined with Experimental Model Systems
7. Long-term Virus Evolution in Nature
8. Quasispecies Dynamics in Disease Prevention and Control
9. Trends in Antiviral Strategies
10. Collective Population Effects in Non-Viral Systems
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included.
The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere.
Esteban Domingo studied chemistry and biochemistry at the University of Barcelona, Spain and spent postdoctoral stays at the University of California, Irvine and the University of Zurich. His main interests are the quasispecies structure of RNA viruses and the development of new antiviral strategies. He is presently Professor of Research of the Spanish Research Council (CSIC) at Centro de Biologia Molecular "Servero Ochoa" in Madrid.