Chapter 2: Synuclein misfolding as a therapeutic target
Chapter 3: Neuroinflammation as a therapeutic target in neurodegenerative diseases
Chapter 4A: Stem cells in neurodegeneration: mind the gap
Chapter 4B: The potential of stem cells in tackling neurodegenerative diseases
Chapter 5: Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy
Chapter 6: Parkinson’s disease
Chapter 7: Lewy body dementia
Chapter 8: Frontotemporal dementia
Chapter 9: From huntingtin gene to Huntington’s disease-altering strategies
Chapter 10: Amyotrophic lateral sclerosis: mechanisms and therapeutic strategies
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.
This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.
- Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
- Summarizes how patients are treated today, providing a glance at future disease management
- Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
- Written and peer reviewed by outstanding scientists in their respective fields
Neuroscientists, graduate and undergraduate students in biological and biomedical sciences, post-doctoral fellows, researchers, neurologists, clinicians
Dr. Veerle Baekelandt obtained a Master of Romance Languages, Master of Biology, and a PhD in Biology at the Katholieke Universiteit (KU) Leuven. She received a Frank Boas Fulbright scholarship for graduate study at Harvard University and became a research fellow in the Laboratory for Neuroscience Research headed by Dr. Larry Benowitz, Children’s Hospital, Harvard Medical School, Boston (1992-1993). Her post-doctoral fellowship looked at gene therapy for neurodegenerative diseases, which became the cornerstone of her own research group.
Dr. Evy Lobbestael obtained her Master’s degree in biomedical sciences in the Faculty of Medicine at the KU Leuven. She completed her PhD training in the laboratory for Neurobiology and Gene Therapy at the KU Leuven under the supervision of Prof. Baekelandt, after obtaining a PhD scholarship from the Research Foundation Flanders. Her doctoral research focused on the function and dysfunction of the Parkinson’s disease-linked gene LRRK2. Besides the development of multiple tools to study LRRK2 including anti-LRRK2 antibodies, LRRK2-encoding lentiviral vectors, and cell lines, she identified protein phosphatase 1 as a physiological regulator of cellular LRRK2 phosphorylation. Currently, she continues her LRRK2 research as a post-doc with a focus on LRRK2 signaling.