Diabetes. Oxidative Stress and Dietary Antioxidants

Description:

While there are some pharmacological treatments for diabetes, they are often marked by unwanted side effects. As a consequence there is a concerted strategy to approach treatment regimens with naturally occurring substances. A plant based approach alone is deficient as there are numerous antioxidants in ordinary foods, such as those in teas, wine, fruits, vegetables which have shown to impede diabetes-related changes. There is also a fundamental need to understand the processes inherent in the oxidative stress of diabetes. While clinical workers understand the processes in diabetes, there are less conversant in the science of nutrition and dietetics. On the other hand nutritionists and dietitians are less conversant with the detailed clinical background of diabetes. Thus, diabetologists, endocrinologists, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance medical sciences and treatments for diabetes.

Diabetes: Oxidative Stress and Dietary Antioxidants aims to bridge the trans-disciplinary divide and to cover in a single volume the science of oxidative stress in diabetes and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation but in concert with other processes such as apoptosis, cell signaling, receptor mediated responses and so on. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this.

The first section of the book, Oxidative Stress and Diabetes, will cover the basic biology of oxidative stress from molecular biology to imaging in relation to diabetes. It will include chapters on neuropathy, nephropathy, atherosclerosis, cardiomyopathy, and retinopathy. The second section, Antioxidants in Foods and Diabetes, will cover antioxidants in foods including plants, components of the diet and their relevance to diabetes.

Edited by Victor R. Preedy, King's College London, School of Biomedical and Health Sciences, London, UK

Features:

• Nutritionists will use the information related to mitochondrial oxidative stress in one disease and propose new diet-related strategies to prevent such conditions arising in another unrelated disease.
• Dietitians will prescribe new foods or diets containing antioxidants for conditions that are refractory by conventional pharmacological treatments.
• Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams.
• Nutritionists and dietitians will learn about cell signaling and will be able to suggest preventive or therapeutic strategies with antioxidant-rich foods to reduce damage done by diseases involving abnormal cell signaling.

Table of Contents:

Oxidative Stress and Diabetes

1. Oxidative stress and diabetic neuropathy
Y. Park, Department of Internal Medicine and Bioengineering, Hanyang University, Seoul, South Korea

2. Oxidative stress in diabetic nephropathy
Prof. A.A. Elmarakby, Medical College of Georgia, Augusta, GA, United States

3. Oxidative stress in diabetic atherosclerosis
Prof. M. Nowicki, Institute of Anatomy, University of Leipzig, Leipzig, Germany

4. Diabetic stroke and oxidative stress
Prof. K. R. Dave, Cerebral Vascular Disease Research Center, University of Miami, Department of Neurology, Miami, FL, United States

5. Diabetic cardiomyopathy and oxidative stress
Prof. K. Watanabe, Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan

6. Oxidative stress in diabetic retinopathy
Prof. G. B. Arden, Henry Wellcome Research Laboratories, Centre for Applied Vision Sciences, Department of Optometry and Visual Science, City University, London, UK

Antioxidants and Diabetes

7. Beta glucan and neuroprotection in diabetes
Prof. H. Alp, Department of Pharmacology and Toxicology, Veterinary Faculty, Dicle University, Diyarbakir, Turkey

8. Selenium and diabetic peripheral neuropathy
Prof. M. Ayaz, Department of Biophysics, Selcuklu Medical Faculty, Selcuk University, Konya, Turkey

9. Neuropathy and micronutrients supplementation
Prof. M.S. Farvid, Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

10. Nigella sativa oil, diabetic neuropathy and oxidative stress
Prof. M. Akhtar, Department of Pharmacology, Hamdard University, New Delhi, India

11. Diabetic nephropathy, propolis and oxidative stress
Prof. O. M. Abo-Salem, Phamacology and Toxicology Departments, Al-Azahar University, Cairo, Egypt

12. Green tea, oxidative stress and diabetic nephropathy
Prof. H. H. Kim, Department of Urology, Seoul National University College of Medicine, Seoul, South Korea

13. Diabetic nephropathy and tocotrienol
Prof. K. Chopra, Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Chandigarh, India

14. Resveratrol, diabetic nephropathy and oxidative stress
Prof. L.-M. Hung, Department and Graduate Institute of Biomedical Sciences, Chang Gung University, Tao-Yuan, Taiwan (Republic of China)

15. Anti-RAGE compounds, atherosclerosis and diabetes
Prof. K.A.M. Jandeleit-Dahm, Diabetes Division, Baker IDI Heart and Diabetes Institute, Melbourne, Australia

16. Vitamin E and vascular protection in diabetes
Prof. A.P. Levy, Department of Anatomy and Cell Biology, Technion Israel Institute of Technology, Haifa, Israel

17. Ginkgo biloba, atherosclerosis protection in diabetes
Prof. K. S. Park, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

18. Zinc supplementation and oxidative stress of vascular tissues Prof. R.C.S. Seet, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

19. Taurine and cardiac oxidative stress
Prof. P.C. Sil, Division of Molecular Medicine, Bose Institute, West Bengal, India

20. Statins, diabetic oxidative stress and vascular tissue
Prof. J.R. Murrow, Emory University School of Medicine, Atlanta, GA, United States

21. Herbal Chrysanthemi Flos, oxidative damage and diabetic vascular protection
Prof. S.-J. Kim, Department of Pharmacology and Toxicology and Metabolic Diseases Research Laboratory, Kyung Hee University, Seoul, South Korea

22. Antioxidant supplements and diabetic retinopathy
Prof. J. J. Garcia-Medina, Ophthalmology Research Unit Santiago Grisolia, University Hospital Doctor Peset, Valencia, Spain

23. Neuroprotective lutein in the retina
Prof. Y. Ozawa, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan

24. Anti-oxidant related micronutrients and diabetic retinopathy
Prof. A.I. Adler, MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

25. Resveratrol, oxidative stress and diabetic liver
Prof. R. Schmatz, Departamento de Quimica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

26. Pomegranate juice, oxidative stress and the lung in diabetes
Prof. G. Eren, Bakirkoy, Dr. Sadi Konuk Training and Research Hospital, Department of Anesthesiology and Intensive Care, Istanbul, Turkey

27. Rosemary extract in diabetes
Prof. C. Barbas, CEMBIO, Universidad San Pablo-CEU, Madrid, Spain

28. Antioxidative effects of allium cepa in diabetes
Prof. N. A. El-soud, National Research Center, Complementary Medicine, Cairo, Egypt

29. Citrus flavonoids and oxidative stress in diabetes
Prof. L. Pari, Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamilnadu, India

30. Oxidative stress, diabetes and iron
Prof. S.R. Marcus, MSU-GEF International Medical School, Bangalore, India

31. Gingseng, diabetes and and oxidative stress
Prof. K. A. Amin, Department of Biochemistry, Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef, Egypt