Progress in Molecular Biology and Translational Science, Vol. 115: Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Description

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

Table of Contents

1. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors
   Michael T. Klein, Paige N. Vinson and Colleen M. Niswender
2. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders
   Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender
3. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery
   Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis
4. G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design
   Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri
5. GPCRs in Stem Cell Function
   Van A. Doze and Dianne M. Perez
6. Application of Receptor Theory to Allosteric Modulation of Receptors
   David A. Hall
7. What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors
   Frederick J. Ehlert
8. Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors
   Jesús Giraldo
9. Chemokine Receptor Oligomerization and Allostery
   Bryan Stephens and Tracy M. Handel
10. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators
    Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac

Author Info

Terry Kenakin, PhD, Professor of Pharmacology, The University of North Carolina at Chapel Hill