In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues of which everyone presumed were unable to regenerate in adults; these include particularly the heart and the brain. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson, diabetes and spinal cord lesions based on the use of stem cells and entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies.
As is often the case in science, many early claims turned out to be different from those expected. Embryonic stem cell therapies have not moved rapidly into clinical practice. Adult stem cells certainly have given certain degrees of success but not nearly to the extent that advocates would have wished for. Some claims of early successes in adult stem cell therapies have not been sustained in double-blinded, randomized clinical trials. Some claims are now close to routine therapy. Some of the claims not supported by evidence have nevertheless reached private clinical practice so that ";stem cell tourism"; is beginning to reach exaggerated proportions.
This book provides the reader background information on stem cells in a clear and well-organized manner. It provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. It distinguishes itself from the multiplicity of websites on the subject of stem cells by being scientifically, politically and ethically neutral, explaining pros and cons for stem cells of every sort with the intention of reaching a wide readership ranging from advanced students and patient advocacy groups to clinicians, specialists and early phase medics in training. By providing the background scientific and social information, it provides readers with the information they require to form their own opinions on the use of stem cells on the basis of facts rather than hype.
- Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy
- Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice
- Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice
- Chapter 1: Biology of the Cell
- Chapter 2: Embryonic development
- Chapter 3: Of mice and men: History of stem cells
- Chapter 4: What are stem cells?
- Chapter 5: Origin of stem cells
- Chapter 6: Types of stem cells
- Chapter 7: Cloning: history and current applications
- Chapter 8: Clinical applications of stem cells
- Chapter 9: Cancer stem cells
- Chapter 10: Applications for drugs and toxicity screening
- Chapter 11: Venturing in stem cells (law and intellectual property)
- Chapter 12: Future Prospects
References and websites
Glossary of terms
By Christine Mummery, Leiden University Medical Center, Department of Anatomy and Embryology, Leiden, The Netherlands; Ian Sir Wilmut, Director, MRC Centre for Regenerative Medicine; Anja Van,De,Stolpe, Hubrecht Institute, Vught, The Netherlands and Bernard Roelen, Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands