Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. It has become increasingly clear that critical interactions between these two organ systems frequently occur. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. However, because these two disciplines developed independently, investigators in each don't always fully appreciate the significance of the other. This book is meant to provide a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated.
The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. Approximately half the book will focus on the role that osteoimmunology plays in the development of human diseases.
This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology - all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact. The book will be written at the level of a graduate school text. It will be easily readable by someone with a college level understanding of biologic science. However, it will contain details that will make it appealing to researchers in any of the relevant areas who want to fully understand the role that interactions between the bone and immune system play in the responses that they are studying.
Pharmaceutical companies are very interested in this topic as it represents a new area for the design of drug targets. The recent development of an antibody therapy against RANK ligand, which was originally identified as a regulator of immune cells, but is now know to also regulate bone resorption, is one example of how research in osteoimmunology can be used to develop a drug.
•Presents a comprehensive, translational source for all aspects of osteoimmunology in one reference work
•Experts in bone biology and immunology (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches.
•Clear presentations by bone biologists of the cellular and molecular mechanisms underlying bone cell development leading to bone and immunological diseases such as Lupus
•Clear presentations by immunologists of how immune cells develop and how the immune system plays a role in bone diseases like osteoporosis and arthritis
Academic, medical, and pharmaceutical researchers in bone biology, immunology, rheumatology, endocrinology, hematology, and periodontia.
"Edited by four pioneers in the field of osteoimmunology, this book contains chapters by 44 outstanding experts, spanning the breadth and depth of our current knowledge of osteoimmunology from cell and molecular biology to clinical problems."
--Tatsuo Suda, Member of the Japan Academy, Associate Member, Science Council of Japan, Emerutus Professor of Showa University, Visiting Professor, Research Center for Genomic Medicine, Saitama Medical University, Japan
"The new textbook of osteoimmunology provides a comprehensive introduction to this recently established field that seeks to bridge two-well established disciplines.
By reviewing both well-established concepts in bone biology and recent advances in our understanding of the interactions between the immune and skeletal systems, the text serves as both an excellent introduction to the field and a state of the art summary. Overall, each chapter provides concise history of work in the area, thus both immunologists and bone biologists can gain a view of how current paradigms evolved to their current states. This makes the book of particular use to trainees that have studied primarily immunology or bone biology in the past but know little about the other. Early chapters focus on specific cell types in the bone such as osteoclasts or osteoblasts and review both the cellular differentiation and function and our current knowledge regarding immune regulation of the cells. Later chapters nicely focus on specific pathologic states in the bone such as inflammatory arthritis or fracture healing and provide a comprehensive review of studies investigating the role of the immune system in these models. The field of osteoimmunology is rapidly expanding and evolving quickly, this textbook will help put all of us on the same page and help us understand how we got here."
--Mary C. Nakamura M.D., Associate Professor of Medicine, UCSF, Division of Rheumatology, San Francisco, CA, USA
Table of Contents
- Chapter 1 Overview: The developing Field of Osteoimmunology
Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi, Joseph Lorenzo
- Chapter 2 The Origins of Bone Cells: Osteoclasts
G. David Roodman, Deborah L. Galson
- Chapter 3 Adaptive Immune Response
David G. Hesslein, Hector L. Aguila, Mark C. Horowitz
- Chapter 4 The Role of Bone Cells in Establishing the Hematopoietic Stem
Henry Kronenberg, Joy Wu
- Chapter 5 The Signaling Pathways Regulating Osteoblast Differentiation
Jane Lian, Gary Stein
- Chapter 6 The Signaling Pathways Regulating Osteoclast Differentiation
Steven Teitelbaum, Roberta Faccio, Hiroshi Takayanagi, Yongwon Choi
- Chapter 7 The Effects of Immune Cells Products (Cytokines and Growth Factors)
on Bone Cells
- Chapter 8 Interactions of Osteoblasts and Osteoclasts
T. John Martin, Natalie A. Sims, Julian M. W. Quinn
- Chapter 9 The Role of the Immune System in the Development of Osteoporosis
Sundeep Khosla, B. Lawrence Riggs, Ulrike I. Moedder
- Chapter 10 The Role of the Immune System in the Bone Loss of Inflammatory
Georg Schett, Steven Goldring
- Chapter 11 The Role of the Immune System in the Bone Loss of Inflammatory
Francisco Sylvester, Anthony T. Vella
- Chapter 12 The Role of the Immune System in Fracture Healing
Louis Gerstenfeld, Thomas Einhorn, Brandon Steen
- Chapter 13 The Role of the Immune System in the Development of Chronic Infections
Brendan Boyce, Edward Schwarz, Lianping Xing
- Chapter 14 The Role of the Immune System in Hematologic Malignancies, which
Gregory Mundy, Claire M. Edwards, Jessica Fowler
- Chapter 15 The Role of the Immune System in Dental Disease
Dana Graves, Rayyan A. Kayal, Thomas Oates, Gustavo Garlet
Edited by Joseph Lorenzo, University of Connecticut Health Center, Farmington, CT, USA; Yongwon Choi, University of Pennsylvania, Philadelphia, PA, USA; Mark Horowitz, Yale University School of Medicine, New Haven, Connecticut, USA and Hiroshi Takayanagi, Tokyo Medical and Dental University, Tokyo, Japan