•Offers an essential introduction to molecular genetics and the ''molecular''
aspects of human disease
•Teaches from the perspective of ''integrative systems biology,'' which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
•In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
•''Traditional'' pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
•Explains the practice of ''molecular medicine'' and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
•Student web site hosts ''self-assessment'' questions; Professor web site hosts all figures from book
•Each chapter ends with Key Summary Points and Suggested Readings
This streamlined ";essential"; version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.
Table of Contents
PART I Essential Pathology - Mechanisms of Disease
- Chapter 1 Cell Injury, Cell Death, and Cellular Adaptation
John J. Lemasters, M.D., Ph.D.
- Chapter 2 Acute and Chronic Inflammation
Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.
- Chapter 3 Infection and Host Response
Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.
- Chapter 4 Neoplasia
William B. Coleman, Ph.D., and Tara Rubinas, M.D.
PART II Concepts in Molecular Biology and Genetics
- Chapter 5 Basic Concepts in Human Molecular Genetics
W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.
- Chapter 6 The Human Genome: Implications for the Understanding of Human
William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.
- Chapter 7 The Human Transcriptome: Implications for the Understanding of
Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.
- Chapter 8 The Human Epigenome: Implications for the Understanding of Human
Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.
- Chapter 9 The Human Proteome: Implications for the Understanding of Human
Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin
- Chapter 10 Integrative Systems Biology: Implications for the Understanding
of Human Disease
M. Michael Barmada, Ph.D. and David C. Whitcomb
PART III Principles and Practice of Molecular Pathology
- Chapter 11 Pathology: The Clinical Description of Human Disease
William K. Funkhouser, M.D., Ph.D.
- Chapter 12 Molecular Pathogenesis: The Biological Basis of Human Disease
William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.
- Chapter 13 Integration of Molecular and Cellular Pathogenesis
Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.
PART IV Molecular Pathology of Human Disease
- Chapter 14 Molecular Basis of Cardiovascular Disease
Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu
- Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases
Nigel S. Key, M.D., and Alice Ma, M.D.
- Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases
Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.
- Chapter 17 Molecular Basis of Diseases of Immunity
David O. Beenhouwer, Ph.D.
- Chapter 18 Molecular Basis of Pulmonary Disease
Dani S. Zander, M.D., and Carol Farver, M.D.
- Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract
Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.
- Chapter 20 Molecular Basis of Liver Disease
Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.
- Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas
Markus M. Lerch, M.D.
- Chapter 22 Molecular Basis of Diseases of the Endocrine System
Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.
- Chapter 23 Molecular Basis of Gynecologic Diseases
Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.
- Chapter 24 Molecular Pathogenesis of Diseases of the Kidney
Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.
- Chapter 25 Molecular Basis of Prostate Disease
William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.
- Chapter 26 Molecular Basis of Breast Disease
Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard
Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium
- Chapter 27 Molecular Basis of Skin Disease
John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.
- Chapter 28 Molecular Basis of Diseases of the Nervous System
Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.
PART V Practice of Molecular Medicine
- Chapter 29 Molecular Diagnosis of Human Disease
Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.
- Chapter 30 Molecular Assessment of Human Disease in the Clinical Laboratory
Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.
- Chapter 31 Pharmacogenomics and Personalized Medicine in the Treatment of
Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.
Edited by William B. Coleman, Associate Professor and Director of Graduate Studies Department of Pathology and Laboratory Medicine Curriculum in Toxicology Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, USA and Gregory J. Tsongalis, Associate Professor, Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH, USA