Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development and discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption and Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery/development phases more quickly.This third edition still stands as the only source for practical aspects of medicinal chemistry by focusing on the daily problems met by the medicinal chemist in drug discovery. New to this edition include: focus on chemoinformatics and drug discovery; enhanced pedagogical features; new chapters including drug absorption and transport, and, multi-target drugs. It includes updates on hot new areas: drug discovery and the latest techniques; how potential drugs can move through the drug discovery/development phases more quickly; and chemoinformatics.
Pt. I - General Aspects of Medicinal Chemistry by Kubinyi, Hugo
- 1 A History of Drug Discovery by Francois Chast
- 2 Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems by Peter Imming
- 3 Measurement and Expression of Drug Effects by Jean-Pierre Nowicki and Bernard Scatton
- 4 Molecular Drug Targets by Jean-Pierre Gies and Yves Landry
- 5 Drug Targets, Target identification, Validation and Screening by Kenton H. Zavitz and Paul L. Bartel and Adrian N. Hobden
Pt. II - Lead Compound Discovery Strategies by Proudfoot, John R.
- 6 Strategies in the Search for New Lead Compounds or Original Working Hypotheses by Camille G. Wermuth
- 7 High-Throughput Screening and Drug Discovery by John R. Proudfoot
- 8 Natural Products as Pharmaceuticals and Sources for Lead Structures by David J. Newman and Gordon M. Cragg and David G. I. Kingston
- 9 Biology Oriented Synthesis and Diversity Oriented Synthesis in Compound Collection Development by Kamal Kumar and Stefan Wetzel and Herbert Waldmann
- 10 In Silico Screening: Hit Finding from Database Mining by Thierry Langer and Sharon D. Bryant
- 11 Fragment-Based Drug Discovery by Bennett T. Farmer and Allen B. Reitz
- 12 Lead-Likeness and Drug-Likeness by Alex Polinsky
- 13 Web Alert: Using the Internet for Medicinal Chemistry by David Cavalla
Pt. III - Primary Exploration of Structure-Activity Relationships by Wermuth, Camille G.
- 14 Molecular Variations in Homologous Series: Vinylogues and Benzologues by Camille G. Wermuth
- 15 Molecular Variations Based on Isosteric Replacements by Paola Ciapetti and Bruno Giethlen