Nitric Oxide. Biology and Pathobiology

Key Features

•Edited by Nobel Laureate Louis J. Ignarro

•Up-to-date therapeutic implications of nitric oxide research
•Authored by world experts on nitric oxide
•Detailed research of the biochemistry and synthesis of nitric oxide

Description

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide’s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.

Contents

Section I. Chemical Biology

• Chapter 1
  Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes
• Chapter 2
  Nitric oxide redox biochemistry in lipid environments
• Chapter 3
  Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration
• Chapter 4
  Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes

Section II. Principles of Biology

A. Nitric Oxide Synthases

• Chapter 5
  Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal
• Chapter 6
  Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases
• Chapter 7
  Regulation of the expression of inducible nitric oxide synthase
• Chapter 8
  Molecular Regulation of Inducible Nitric Oxide Synthase

B. Guanylate Cyclase and Cyclic GMP

• Chapter 9
  Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation

C. Nitric Oxide Signaling

• Chapter 10
  Untargeted Discovery of NO-modified Proteins
• Chapter 11
  Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids
• Chapter 12
  Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1
• Chapter 13
  The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide

D. Regulation of Nitric Oxide Production

• Chapter 14
  Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence

E. Nitric Oxide and Remodeling

• Chapter 15
  The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies

F. Nitrite and Nitrate

• Chapter 16
  NO formation from inorganic nitrate and nitrite
• Chapter 17
  Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential
• Chapter 18
  Nitrite Therapy for Ischemic Syndromes
• Chapter 19
  Nitrite and heme globins: Reaction mechanisms and physiological targets

Section III. Principles of Pathobiology

A. Nitric Oxide and Cardiovascular Function

• Chapter 20
  Nitric Oxide in Vascular Damage and Regeneration
• Chapter 21
  Free radicals as atherosclerotic risk-The relation of NO-
• Chapter 22
  The role of oxidative stress in endothelial dysfunction and vascular inflammation

B. Pathophysiological Mechanisms of Nitric Oxide

• Chapter 23
  Nitric oxide, oxidative stress, immune response and critical care
• Chapter 24
  Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury
• Chapter 25
  Nitric oxide in airway inflammation
• Chapter 26
  Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance

Author Information

Edited by Louis J. Ignarro, Center for Health Sciences, UCLA School of Medicine, Los Angeles, California, U.S.A.