Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.
Audience: Neuroscientists, molecular biologists, pharmacologists, neurologists, neurology residents, and clinical researchers.
Chapter 1 Genetics as a Tool in Neurology Dennis R. Johnson, Fuki M. Hisama Chapter 2 Neurology and Genomic Medicine Jeffery Vance Chapter 3 Mitochondrial Function and Dysfunction in the Nervous System Neggy Rismanchi and Craig Blackstone Chapter 4 Neuronal Channels and Receptors Alan L. Goldin Chapter 5 Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System Cindy Voisine, Kai Orton, and Richard I. Morimoto Chapter 6 Metabolic Biopsy of the Brain Ognen A. C. Petroff Chapter 7 Gene therapy approaches in neurology Edward A. Burton, Joseph C. Glorioso, David J. Fink Chapter 8 Programmed Cell Death and its Role in Neurological Disease D. E. Bredesen, R. V. Rao and P. Mehlen1 Chapter 9 Developmental Neurology: A Molecular Perspective Juan M. Pascual Chapter 10 Metabolic Diseases of the Nervous System Juan M. Pascual Chapter 11 Genetic Disorders of Neuromuscular Development Juan M. Pascual Chapter 12 Molecular Mechanisms of Ischemic Brain Disease Thomas M. Hemmen, Justin A. Zivin Chapter 13 Hemorrhagic Brain Disease Michael L. DiLuna, Kaya Bilguvar, Gamze Tanriover, Murat Gunel Chapter 14 The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury Noam Y. Harel, Yvonne S. Yang, Stephen M. Strittmatter, Jeffery D. Kocsis, and Stephen G. Waxman Chapter 15 Parkinson?s Disease: Molecular Insights Ted M. Dawson, Josesph M. Savitt, Valina L. Dawson Chapter 16 The molecular basis of Alzheimer?s disease Martin Ingelsson, Bradley T. Hyman Chapter 17 Polyglutamine Disorders including Huntington?s Disease Sokol V. Todi, Aislinn J. Williams, Henry L. Paulson Chapter 18 Friedreich?s Ataxia and Related RNA Loss-Of-Function Disorders Masimo Pandolfo Chapter 19 DYT1, a Primary Torsion Dystonia Susan B. Bressman, Laurie Ozelius Chapter 20 Motor Neuron Disease: Amyotrophic Lateral Sclerosis Nicholas J. Maragakis and Jeffrey D. Rothstein Chapter 21 Genetic Disorders of the Autonomic Nervous System Stephen J. Peroutka Chapter 22 Multiple sclerosis as a neurodegenerative disease Stephen G. Waxman Chapter 23 Acquired Epilepsy: Cellular and Molecular Mechanisms Christopher B. Ransom and Hal Blumenfeld Chapter 24 Disorders of Excitation and Transmission: Genetic Epilepsies Ingo Helbig, Ingrid E. Scheffer and Samuel F. Berkovic Chapter 25 Hyperekplexia (startle disease / stiff baby syndrome): Molecular pathology of the glycine receptor complex Cord-Michael Becker Chapter 26 Tourette?s Syndrome James F. Leckman, Michael H. Bloch Chapter 27 Disorders of Sleep and Circadian Rhythms Sebastiaan Overeem, Gert Jan Lammers, Mehdi Tafti Chapter 28 Chronic pain as a molecular disorder John N Wood and Stephen G Waxman Chapter 29 Migraine as a cerebral ionopathy with impaired central sensory processing Michel D Ferrari, Arn M.J.M. van den Maagdenberg, Rune R. Frants, and Peter J. Goadsby Chapter 30 Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies John A. Kamholz Chapter 31 Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis Alexander Flugel, Hartmut Wekerle Chapter 32 Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal Angela Vincent Chapter 33 Paraneoplastic Neurologic Syndromes Josep Dalmau Chapter 34 Mitochondrial Disorders Salvator DiMauro, Eric A. Schon Chapter 35 Molecular Neurology of HIV-1 Infection and AIDs Markus Kaul, Stuart A. Lipton