“This is the most comprehensive book ever written about gastroesophageal
reflux disease. Dr. Tom R. DeMeester has been the leading authority on this
disease of the 20th century, and has headed for the last 15 years one of the
most productive units of foregut surgery in the world. Dr. Chandrasoma has recently
emerged as a leading pathologist in this area. The authors have extensively
covered all aspects of gastroesophageal reflux disease, from the anatomy to
the pathophysiology, from the diagnosis to the rationale for treatment. They
have carefully reviewed the literature in view of their own experience, explaining
how this disease can progress from symptoms to cancer.
An essential reading for whoever treats patients with gastroesophageal reflux disease, from gastroenterologists to surgeons.”
--Marco G. Patti, MD, Professor of Surgery, University of California, San Francisco
"One would be hard pressed to find a better collaboration to characterize
the total clinical spectrum of esophageal adenocarcinoma than Tom DeMeester
and Para Chandrasoma. This textbook is rich with the fruits of the knowledge
and experience of these two outstanding investigators, including not only the
full range of commonly accepted knowledge and beliefs in this field but also
developing concepts on the histopathologic relationship between chronic reflux
and injury to the distal esophageal mucosa that have resulted from detailed
observation and clinical research from this illustrious team. Failure to appreciate
the histologic changes that occur with, and therefore predict, the process of
development of adenocarcinoma leave the clinician with a false sense of understanding.
As the authors state, “most influential physicians on the subject today
simply do not look through the microscope and have no true understanding of
histology.” The approach that this team follows at the University of Southern
California is based on their belief that “to be successful, the super
specialized clinical esophagologist must understand the significance of the
microscopic pathology of the biopsies that are taken, and the super specialized
esophageal pathologist must understand the clinical basis of columnar-lined
esophagus." All of us who are involved in the care of patients with esophageal
adenocarcinoma owe a debt of gratitude to Drs. DeMeester and Chandrasoma for
producing the exceptional material contained within this text."
--Donald O. Castell, MD, Professor of Medicine, Director, Esophageal Disorders Program, Medical University of South Carolina
The increasing incidence of esophageal adenocarcinoma has created an enormous interest and stimulus for research in this area. GERD brings together, for the first time, a vast amount of disparate literature and documents the entire pathogenesis of reflux disease in one place. The book presents reflux carditis as a new diagnostic criterion of GERD and for the first time defines the dilated end-stage esophagus and the earliest microscopic phase of GERD that is missed by present diagnostic criteria. GERD presents both clinical and pathological information and is meant to be used as a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike.