Gerd Reflux to Esophageal Adenocarcinoma

Outlines how gastroesophageal reflux causes cellular changes in the esophagus

Brings together the pathogenesis of the disease in one source and applies it toward clinical treatment

Tom DeMeester is THE leading international expert on reflux disease; Parakrama Chandrasoma is one of the leading pathologists in the area

Book contains approximately 350 illustrations

Ancillary web site features color illustrations: www.chandrasoma.com

Reviews

“This is the most comprehensive book ever written about gastroesophageal reflux disease. Dr. Tom R. DeMeester has been the leading authority on this disease of the 20th century, and has headed for the last 15 years one of the most productive units of foregut surgery in the world. Dr. Chandrasoma has recently emerged as a leading pathologist in this area. The authors have extensively covered all aspects of gastroesophageal reflux disease, from the anatomy to the pathophysiology, from the diagnosis to the rationale for treatment. They have carefully reviewed the literature in view of their own experience, explaining how this disease can progress from symptoms to cancer.
An essential reading for whoever treats patients with gastroesophageal reflux disease, from gastroenterologists to surgeons.”
--Marco G. Patti, MD, Professor of Surgery, University of California, San Francisco

"One would be hard pressed to find a better collaboration to characterize the total clinical spectrum of esophageal adenocarcinoma than Tom DeMeester and Para Chandrasoma. This textbook is rich with the fruits of the knowledge and experience of these two outstanding investigators, including not only the full range of commonly accepted knowledge and beliefs in this field but also developing concepts on the histopathologic relationship between chronic reflux and injury to the distal esophageal mucosa that have resulted from detailed observation and clinical research from this illustrious team. Failure to appreciate the histologic changes that occur with, and therefore predict, the process of development of adenocarcinoma leave the clinician with a false sense of understanding. As the authors state, “most influential physicians on the subject today simply do not look through the microscope and have no true understanding of histology.” The approach that this team follows at the University of Southern California is based on their belief that “to be successful, the super specialized clinical esophagologist must understand the significance of the microscopic pathology of the biopsies that are taken, and the super specialized esophageal pathologist must understand the clinical basis of columnar-lined esophagus." All of us who are involved in the care of patients with esophageal adenocarcinoma owe a debt of gratitude to Drs. DeMeester and Chandrasoma for producing the exceptional material contained within this text."
--Donald O. Castell, MD, Professor of Medicine, Director, Esophageal Disorders Program, Medical University of South Carolina

Description

The increasing incidence of esophageal adenocarcinoma has created an enormous interest and stimulus for research in this area. GERD brings together, for the first time, a vast amount of disparate literature and documents the entire pathogenesis of reflux disease in one place. The book presents reflux carditis as a new diagnostic criterion of GERD and for the first time defines the dilated end-stage esophagus and the earliest microscopic phase of GERD that is missed by present diagnostic criteria. GERD presents both clinical and pathological information and is meant to be used as a comprehensive reference for gastroenterologists, esophageal surgeons, and pathologists alike.

Contents

Overview of Gastroesophageal Reflux Disease

The Past, Present and Future of Columnar Lined (Barrett) Esophagus

Fetal Development of the Esophagus and Stomach

Normal Anatomy; Present Definition of the Gastroesophageal Junction

Histologic Definitions and Diagnosis of Epithelial Types

Cardiac Mucosa

New Histologic Definitions of Esophagus, Stomach and Gastroesophageal Junction

Pathology of Reflux Disease at a Cellular Level: Part 1 – Damage to Squamous Epithelium and Transformation into Cardiac Mucosa

The Pathology of Reflux Disease at Cellular Level: Part 2- Evolution of Cardiac Mucosa to Oxyntocardiac Mucosa and Intestinal Metaplasia

Pathology of Reflux Disease at Cellular Level: Part 3 – Intestinal (Barrett) Metaplasia to Carcinoma

Pathology of Reflux Disease at Anatomic Level

Reflux Disease Limited to the Dilated End-Stage Esophagus: The Pathologic Basis of NERD

Definition of Gastroesophageal Reflux Disease and Barrett Esophagus

Diagnosis of Gastroesophageal Reflux Disease, Barrett Esophagus and Dysplasia

Research Strategies for preventing reflux-induced adenocarcinoma

Rationale of Treatment of Reflux Disease and Barrett Esophagus

Treatment Strategies for preventing reflux-induced adenocarcinoma