This book is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.
Scientists and researchers in neuroscience, neurology, neurosurgery, psychiatry, physical medicine and rehabilitation, as well as graduate students and fellows preparing for board examinations.
Part I. Central Nervous System Section A. Metabolic Diseases – Hugo W. Moser Chapter 1: Leukodystrophies Chapter 2: Lysosomal Disorders of the Nervous System Chapter 3: The Neurobiology of Peroxisomal Disorders Chapter 4: Creatine Deficiency Syndromes Section B. Neurodegenerative Disorders – Gregor Wenning Chapter 5: Parkinson?s Disease Chapter 6: Alzheimer Disease Chapter 7: Multiple System Atrophy Chapter 8: Olivopontocerebellar Atrophy (OPCA) Chapter 9: Neurobiology of Progressive Supranuclear Palsy Section C. Genetic Diseases – Christopher Gomez Chapter 10: Protein Aggregation Disorders Chapter 11: RNA-Based Disorders of Muscle and Brain Chapter 12: Ion Channel Disorders Chapter 13: Spinocerebellar Ataxia Type 1 Chapter 14: Shared Transcriptional Consequences of Mitochondrial Disease, Ischemic Hypoxia and Chemical Hypoxia Section D. Neuroimmunological Disorders – Anthony T. Reder Chapter 15: Paraneoplastic Neurological Disorders Chapter 16: Systemic Lupus Erythematosus: Descriptive Past and Mechanistic Future Chapter 17: Progressive Multifocal Leukoencephalopathy Chapter 18: Multiple Sclerosis Chapter 19: Immune-Mediated Neuropathies Chapter 20: Hashimoto Encephalopathy Section E. Cerebrovascular Diseases – Lewis Morgenstern Chapter 21: Vascular Cognitive Impairment Chapter 22: Cardioembolism Chapter 23: Coagulation Disorders Chapter 24: Clinical and Neurobiological Aspects of Stroke Recovery Chapter 25: Non-Atherosclerotic Cerebral Vasculopathies Chapter 26: Subarachnoid Hemorrhage Chapter 27: Cerebral Ischemia: Molecular Mechanisms and Protective Therapies Chapter 28: Intracerebral Hemorrhage and Intraventricular Hemorrhage-Induced Brain Injury Section F. Paroxysmal Disorders – Timothy A. Pedley Chapter 29: Idiopathic Epilepsies Chapter 30: Paroxysmal Dyskinesia Chapter 31: Neurobiology of Myoclonus Chapter 32: Channelopathies of the Nervous System Chapter 33: Migraine Chapter 34: Temporal Lobe Epilepsy Section G. Neoplastic Diseases – John Laterra Chapter 35: CNS Metastases Robert J. Weil Chapter 36: Meningioma Katrin Lamszus, Christian Hagel, and Manfred Westphal Chapter 37: CNS Lymphoma Corresponding Author: Dr. Batchelor Chapter 38: Neurofibromatosis 1 Linda Piersall and David H. Gutmann Chapter 39: Medulloblastoma and Primitive Neuroectodermal Tumors Said Elshihabi and James T. Rutka Chapter 40: Glioma Anders I. Persson, QiWen Fan, Joanna J. Phillips, and William A. Weiss Section H. Infectious Diseases – Richard T. Johnson Chapter 41: Bacterial & Fungal Chapter 42: Parasitic Infections Chapter 43: Prion Diseases Chapter 44: Central Nervous System Viral Infections: Clinical Aspects and Pathogenic Mechanisms Section I. Motor Neuron Diseases – Eva L. Feldman Chapter 45: Spinal Muscular Atrophy Chapter 46: Amyotrophic Lateral Sclerosis-Like Syndromes Associated with Malignancy Chapter 47: Amyotrophic Lateral Sclerosis (ALS): Idiopathic and Inherited Chapter 48: Hereditary Spastic Paraplegia and Primary Lateral Sclerosis Chapter 49: Poliomyelitis Chapter 50: Spinobulbar Muscular Atrophy (Kennedy?s Disease) Section J. Malformations and Developmental Disorders – Michael V. Johnston Chapter 51: Neurobiology of Genetic Mental Retardation Chapter 52: Cerebral Palsy Chapter 53: Autism Chapter 54: Neurobiology of Dyslexia Chapter 55: Neonatal Brain Injuries Chapter 56: Spina Bifida Chapter 57: Circuits to Synapses: The Pathophysiology of Tourette Syndrome Chapter 58: Attention Deficit Hyperactivity Disorder Chapter 59: Congenital Hydrocephalus Section K. Neurologic Manifestations of Medical Diseases – John J. Caronna Chapter 60: Hematological Disorders Chapter 61: Renal Disease Chapter 62: Diabetes and Endocrine Disorders Chapter 63: Mechanisms and Consequences of CNS Hypoxia Chapter 64: Gastroenterologic and Hepatic Diseases and Their Effects on CNS Chapter 65: Sarcoidosis Section L. Sleep Disorders – Emmanuel Mignot Chapter 66: REM Sleep Behavior Disorder Chapter 67: The Neurobiology of Narcolepsy and Hypersomnia Chapter 68: Restless Legs Syndrome and Periodic Leg Movement Chapter 69: Obstructive Sleep Apnea Chapter 70: The Neurobiology of Insomnia Section M. Substance Abuse and Basic Toxicology – John C. M. Brust Chapter 71: Organic Chemicals Chapter 72: Metals Chapter 73: Drug Addiction Section N. Imaging the Nervous System – John C. Mazziotta Chapter 74: Assessment of Neurobiological Diseases with Magnetic Resonance Spectroscopy Chapter 75: Magnetic Resonance Imaging Chapter 76: Neurovascular CT Angiography Chapter 77: PET Imaging in Parkinson's Disease and Other Neurodegenerative Disorders Chapter 78: Single Photon Emission Computed Tomography (SPECT) Chapter 79: Functional Magnetic Resonance Imaging (fMRI)
Part II. Peripheral Nervous System Section O. Peripheral Neuropathies – James Russell Chapter 80: Diabetic and Metabolic Neuropathies Chapter 81: Aquired Inflammatory Demyelinating and Axonal Neuropathies Chapter 82: Toxic and Drug-Induced Neuropathies Chapter 83: Hereditary Neuropathies Chapter 84: Neurological Manifestations of Vasculitis Chapter 85: Neuropathies Associated with Infections Section P. Myopathies and neuromuscular junction disorders – Charles A. Thornton Chapter 86: The Muscular Dystrophies Chapter 87: Myasthenia Gravis and Myasthenic Syndromes Chapter 88: Myopathies and Neuromuscular Junction Disorders Chapter 89: Immunobiology of Autoimmune Inflammatory Myopathies Section Q. Autonomic Disorders – Phillip A. Low Chapter 90: Central Autonomic Network Chapter 91: Autonomic Neuropathies Chapter 92: Thermoregulation and its Disorders Chapter 93: Control of Blood Pressure-Normal and Abnormal Section R. Pain – Kenneth L. Casey Chapter 94: Neoplasm-Induced Pain Chapter 95: Pain Associated with the Autonomic Nervous System Chapter 96: Post-Herpetic Neuralgia Chapter 97: Central Post-Stroke Pain